In Pakistan, the HIV situation has gone from an outbreak to a concentrated epidemic, and the virus has now crossed into the low-risk population. In addition, several new HIV outbreaks have occurred in different parts of the country. HIV-1 subtype A has been the major epidemic subtype in Pakistan; however, as the epidemic has grown, the emergence of several new subtypes and recombinant forms has been observed. Here, we present the first case and genetic analysis of an unassigned, complex recombinant form in a Pakistani HIV-infected individual with virological failure. Genetic analysis of the sequence indicated that this recombinant form is multi-drug resistant, harboring drug resistance mutations against more than one class of antiretroviral drugs.

中文翻译：

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未分配的复杂重组体在巴基斯坦HIV感染者中的出现。

在巴基斯坦，艾滋病毒的流行已经从爆发变成了集中流行，现在这种病毒已经传播到低风险人群中。此外，该国不同地区又发生了几起新的艾滋病毒暴发。HIV-1 A亚型是巴基斯坦的主要流行亚型。然而，随着流行病的发展，已经观察到几种新的亚型和重组形式的出现。在这里，我们介绍了巴基斯坦艾滋病毒感染者病毒学失败的未分配，复杂的重组形式的第一个病例和遗传分析。对该序列的遗传分析表明，这种重组形式具有多重耐药性，对多于一类的抗逆转录病毒药物具有耐药性突变。