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1,2,4-Triphenylpyrroles: Synthesis, Structure and Luminescence Properties
Synlett ( IF 1.7 ) Pub Date : 2020-02-13 , DOI: 10.1055/s-0039-1690828
Joana R. M. Ferreira 1 , Raquel Nunes da Silva 1, 2 , João Rocha 3 , Artur M. S. Silva 1 , Samuel Guieu 1, 3
Affiliation  

Pyrroles are widely found in natural products and play an important role in biological processes. Certain pyrrole derivatives are fluorescent and may be used as molecular probes or biomarkers in the diagnosis of diseases, such as Alzheimer’s or Parkinson’s. Herein is reported the synthesis of five new pyrrole derivatives bearing phenyl rings on positions 1, 2, and 4, with electron-donating groups at the periphery. The introduction of more or stronger electron-donating groups red-shifts and increases the efficiency of the fluorescence emission.

中文翻译:

1,2,4-三苯基吡咯:合成、结构和发光特性

吡咯广泛存在于天然产物中,并在生物过程中发挥重要作用。某些吡咯衍生物具有荧光性,可用作诊断疾病(例如阿尔茨海默氏症或帕金森氏症)的分子探针或生物标志物。本文报道了五种新的吡咯衍生物的合成,它们在 1、2 和 4 位带有苯环,外围带有给电子基团。引入更多或更强的给电子基团会发生红移并提高荧光发射的效率。
更新日期:2020-02-13
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