According to the statistics of the World Health Organization, an estimated 17.9 million people die from cardiovascular diseases each year, representing 31% of all global deaths. Continuous non-invasive arterial pressure (CNAP) is essential for the management of cardiovascular diseases. However, it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression. Here, we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP. We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts, and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices. We compare the results with the blood pressure acquired by invasive (intra-arterial) blood pressure monitoring for >1500 min in total on 44 subjects in an intensive care unit. The maximum absolute errors of diastolic and systolic blood pressure were ±7/±10 mm Hg, respectively, in immobilized, and ±10/±14 mm Hg, respectively, in walking scenarios. These strategies provide advanced blood pressure monitoring techniques, which would directly address an unmet clinical need or daily use for a highly vulnerable population.

中文翻译：

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可穿戴类肤光电系统，可抑制无袖连续血压监测仪的运动伪影

据世界卫生组织统计，每年估计有1790万人死于心血管疾病，占全球死亡人数的31%。连续无创动脉压（CNAP）对于心血管疾病的治疗至关重要。然而，由于对皮肤的刺激以及缺乏运动伪影抑制，现有设备的日常使用很难实现长期 CNAP 监测。在这里，我们报告了一种集成超薄柔性电路的高性能类皮肤光电系统，用于监测 CNAP。我们通过虚拟工作原理引入了一个理论模型，用于预测精确的血压和抑制运动伪影，并提出了频域中的光学差异，以实现类皮肤设备的稳定光学测量。我们将结果与重症监护病房 44 名受试者总共超过 1500 分钟的有创（动脉内）血压监测获得的血压进行比较。固定时舒张压和收缩压的最大绝对误差分别为±7/±10毫米汞柱，步行情况下分别为±10/±14毫米汞柱。这些策略提供了先进的血压监测技术，可直接解决高度脆弱人群未满足的临床需求或日常使用。