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A microfluidic approach to micromembrane synthesis for complex release profiles of nanocarriers.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-02-26 , DOI: 10.1039/d0lc00039f Nan Jia 1 , Erica Rosella 1 , Estelle Juère 2 , Roxane Pouliot 3 , Freddy Kleitz 2 , Jesse Greener 4
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-02-26 , DOI: 10.1039/d0lc00039f Nan Jia 1 , Erica Rosella 1 , Estelle Juère 2 , Roxane Pouliot 3 , Freddy Kleitz 2 , Jesse Greener 4
Affiliation
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Physically crosslinked microscale biomembranes synthesized from pure chitosan are designed and demonstrated for pH-triggered release of embedded functionalized mesoporous silica nanoparticles. Nanoparticle-loaded membranes are formed in a microfluidic channel at the junction between accurately controlled co-flowing streams to achieve highly tuneable membrane properties. After formation, the loaded membranes remain stable until contact with physiological acidic conditions, resulting in controlled nanoparticle release. Furthermore, nanoparticle-loaded membranes with complex layered architectures are synthesized using different flow schemes, thus enabling customized nanoparticle release profiles. These novel materials are well-suited for integration within small medical devices as well as off-chip applications.
中文翻译：
用于微载体合成的微流体方法，用于纳米载体的复杂释放曲线。
设计并证明了从纯壳聚糖合成的物理交联的微型生物膜可用于pH触发释放嵌入式功能化介孔二氧化硅纳米粒子。负载纳米颗粒的膜在精确控制的同流流之间的连接处的微流体通道中形成，以实现高度可调节的膜性能。形成后，加载的膜保持稳定，直到与生理酸性条件接触，导致受控的纳米颗粒释放。此外，使用不同的流程方案可以合成具有复杂分层结构的纳米颗粒负载膜，从而实现定制的纳米颗粒释放曲线。这些新颖的材料非常适合在小型医疗设备以及片外应用中集成。
更新日期：2020-03-19
中文翻译：
用于微载体合成的微流体方法，用于纳米载体的复杂释放曲线。
设计并证明了从纯壳聚糖合成的物理交联的微型生物膜可用于pH触发释放嵌入式功能化介孔二氧化硅纳米粒子。负载纳米颗粒的膜在精确控制的同流流之间的连接处的微流体通道中形成，以实现高度可调节的膜性能。形成后，加载的膜保持稳定，直到与生理酸性条件接触，导致受控的纳米颗粒释放。此外，使用不同的流程方案可以合成具有复杂分层结构的纳米颗粒负载膜，从而实现定制的纳米颗粒释放曲线。这些新颖的材料非常适合在小型医疗设备以及片外应用中集成。
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