Tau hyperphosphorylation is an early step in tau‐mediated neurodegeneration and is associated with intracellular aggregation of tau as neurofibrillary tangles, neuronal and synaptic loss, and eventual cognitive dysfunction in Alzheimer disease. Sleep loss increases the cerebrospinal fluid concentration of amyloid‐β and tau. Using mass spectrometry, we measured tau and phosphorylated tau concentrations in serial samples of cerebrospinal fluid collected from participants who were sleep‐deprived, treated with sodium oxybate, or allowed to sleep normally. We found that sleep loss affected phosphorylated tau differently depending on the modified site. These findings suggest a mechanism for sleep loss to increase risk of Alzheimer disease. ANN NEUROL 2020;87:700–709

中文翻译：

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睡眠剥夺影响人脑脊液中的 tau 磷酸化

Tau 过度磷酸化是 tau 介导的神经变性的早期步骤，并且与细胞内 tau 聚集作为神经原纤维缠结、神经元和突触丢失以及最终的阿尔茨海默病认知功能障碍有关。睡眠不足会增加淀粉样蛋白-β 和 tau 的脑脊液浓度。我们使用质谱法测量了从睡眠剥夺、接受羟丁酸钠治疗或允许正常睡眠的参与者收集的脑脊液系列样本中的 tau 和磷酸化 tau 浓度。我们发现睡眠不足对磷酸化 tau 的影响因修饰位点而异。这些发现表明睡眠不足会增加阿尔茨海默病风险的机制。神经网络 2020;87:700–709