Multiple point mutations in PsORP1 gene conferring different resistance levels to oxathiapiprolin confirmed using CRISPR-Cas9 in Phytophthora sojae.,Pest Management Science

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Multiple point mutations in PsORP1 gene conferring different resistance levels to oxathiapiprolin confirmed using CRISPR-Cas9 in Phytophthora sojae.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-02-14 , DOI: 10.1002/ps.5784
Jianqiang Miao ₁ , Xiaofei Liu ₁ , Guixiang Li ₁ , Xiaoran Du ₁ , Xili Liu _{1,

2}

Affiliation

Oxathiapiprolin is among the first commercial oxysterol‐binding protein inhibitors (OSBPIs) developed by DuPont Corporation and shows excellent activity against plant‐pathogenic oomycetes. Although more than 21 target site mutations have been identified in insensitive oomycetes, only G770V, G839W, and ΔN837 have been verified to confer oxathiapiprolin resistance in Phytophthora capsici or P . sojae . The effect of other mutations on OSBPIs sensitivity requires urgent investigation.

中文翻译：

使用 CRISPR-Cas9 在大豆疫霉中证实了 PsORP1 基因的多个点突变对 oxathiapiprolin 具有不同的抗性水平。

Oxathiapiprolin 是杜邦公司开发的首批商业化氧甾醇结合蛋白抑制剂 (OSBPI) 之一，对植物病原性卵菌表现出优异的活性。尽管在不敏感卵菌中已鉴定出超过 21 个靶位点突变，但只有 G770V、G839W 和 ΔN837 已被证实可赋予辣椒疫霉或疫霉中的 oxathiapiprolin 抗性。酱油。其他突变对 OSBPI 敏感性的影响需要紧急研究。

更新日期：2020-02-14

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