With an increasing interest in exploring the biocatalyst potential for the production of natural products (NP), research in NP biotechnology now follows. Xanthones constitute an important class of phytochemicals exhibiting a myriad of bioactivities and potential for interacting with multimolecular targets, and xanthones are considered to be privileged phytochemical scaffolds in medicinal chemistry. Recent advances in xanthones biosynthetic pathways are outlined and their metabolic engineering. This review summarizes the state-of-the-art processes for the biotechnological production of xanthones, its limitations, and potential improvements. The in vitro tissue culturing methods employed for the production of xanthones from different species of plant are reviewed addressing differences in xanthone classes. This review sheds the light of computational approaches, viz., response surface methodology (RSM) and artificial neural networks (ANN), for optimizing the culture performance and improving xanthones production.

中文翻译：

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利用培养的植物生物催化剂模型并借助计算机内工具进行优化的黄原酮生产的现状和前景。

随着对探索生产天然产物（NP）的生物催化剂潜力的兴趣日益浓厚，现在进行NP生物技术的研究。氧杂蒽酮是一类重要的植物化学物质，其表现出无数的生物活性和与多分子靶标相互作用的潜力，并且氧杂蒽酮被认为是药物化学中的优先植物化学支架。概述了氧杂蒽酮生物合成途径的最新进展及其代谢工程。这篇综述总结了氧杂蒽酮生物技术生产的最新工艺，其局限性和潜在的改进。审查了用于从不同植物物种生产氧杂蒽酮的体外组织培养方法，以解决黄酮类的差异。