Fabrication of Copper‐based Silica‐coated Magnetic Nanocatalyst for Efficient One‐pot Synthesis of Chalcones via A3 Coupling of Aldehydes‐Alkynes‐Amines,ChemCatChem

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Fabrication of Copper‐based Silica‐coated Magnetic Nanocatalyst for Efficient One‐pot Synthesis of Chalcones via A3 Coupling of Aldehydes‐Alkynes‐Amines
ChemCatChem ( IF 3.8 ) Pub Date : 2020-03-23 , DOI: 10.1002/cctc.202000148
Priya Yadav _{1,

2} , Manavi Yadav _{1,

2} , Rashmi Gaur ₁ , Radhika Gupta ₁ , Gunjan Arora ₁ , Pooja Rana ₁ , Anju Srivastava ₂ , Rakesh K. Sharma ₁

Affiliation

In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica‐coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility for the solvent‐free one‐pot synthesis of chalcone moieties by A³ coupling of aldehydes‐alkynes‐amines in good to excellent yields. The fabricated Cu@DBM@ASMNPs was structurally and chemically analyzed by various techniques such as FT‐IR, SEM, TEM, VSM, ICP‐MS, ED‐XRF and XPS. The programmed catalytic protocol has been proceeded via isomerization‐hydrolysis reaction of aldehydes and terminal alkynes. The present strategy offered much greener and efficacious synthesis of chalcones by adding benefits such as solvent‐less synthetic protocol and much shorter reaction time. Other interesting and noteworthy features of this methodology are broad substrate scope, mild reaction conditions, and reusability up to seven runs without significant loss of its catalytic activity which renders it an environmentally friendly and remarkable protocol from industrial point of view.

中文翻译：

铜基二氧化硅包覆的磁性纳米催化剂的制备，可通过醛-炔-胺的A3偶联有效地一锅法合成Ch。

在目前的工作中，我们通过使用绿色高效的二氧化硅包覆的磁可分离催化剂Cu @ DBM @ ASMNPs合成了具有生物活性和重要药学意义的查尔酮基序。高效的纳米催化剂通过醛-炔烃-胺的A ³偶联以良好的收率证明了其无溶剂一锅法合成查尔酮部分的能力。通过诸如FT-IR，SEM，TEM，VSM，ICP-MS，ED-XRF和XPS等各种技术对制成的Cu @ DBM @ ASMNPs进行结构和化学分析。编程的催化方案已通过醛和末端炔烃的异构化水解反应。通过增加诸如无溶剂合成方案和更短的反应时间之类的好处，本策略提供了更环保，更有效的查耳酮合成方法。该方法的其他有趣且值得注意的特征是广泛的底物范围，温和的反应条件以及最多可进行七次运行的可重复使用性，而不会显着降低其催化活性，这使其从工业角度出发成为环保且引人注目的方案。

更新日期：2020-03-23

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