BACKGROUND Around twenty million new cases and ten million of deaths were attributed to cancer in 2018. Physical exercise, as main component of prehabilitation programs, has been associated with clinical improvements in aerobic capacity, muscular strength, gait speed, and fewer postoperative complications. This systematic review aims to determine the benefits and harms of prehabilitation programs, mainly composed of physical exercise, compared with standard care for cancer patients. METHODS/DESIGN A librarian will systematically search for randomized controlled trials in the following databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (PubMed), and EMBASE. Two independent reviewers will independently screen the retrieved references, appraise the methodological quality of the included studies, and extract data. If possible, we will pool the data. We will evaluate the completeness of reporting of prehabilitation programs by using the CERT checklist, and the GRADE approach will be used to evaluate the quality of the evidence. DISCUSSION This systematic review will determine the benefits and harms of prehabilitation programs for cancer patients. We will provide a complete appraisal of the quality of the evidence, our confidence in the results, and completeness of reporting of the exercise interventions evaluated in the prehabilitation programs. Findings from this review will assist health care providers, patients, decision-makers, and international organizations to make informed decisions in this field. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42019125658.

中文翻译：

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癌症患者的康复计划：随机对照试验的系统评价（方案）。

背景 2018 年，约有 2000 万新发病例和 1000 万癌症死亡病例。体育锻炼作为康复计划的主要组成部分，与临床有氧能力、肌肉力量、步态速度的改善和术后并发症的减少有关。这项系统评价旨在确定以体育锻炼为主的康复计划与癌症患者标准护理相比的利弊。方法/设计 图书馆员将在以下数据库中系统地检索随机对照试验：Cochrane 对照试验中心注册库 (CENTRAL)、MEDLINE (PubMed) 和 EMBASE。两名独立评审员将独立筛选检索到的参考文献，评估纳入研究的方法学质量并提取数据。如果可能的话，我们将汇集数据。我们将使用 CERT 检查表来评估康复计划报告的完整性，并使用 GRADE 方法来评估证据的质量。讨论 本系统评价将确定癌症患者康复计划的益处和危害。我们将对证据的质量、我们对结果的信心以及预康复计划中评估的运动干预报告的完整性进行完整的评估。此次审查的结果将帮助医疗保健提供者、患者、决策者和国际组织在这一领域做出明智的决定。系统审查注册 PROSPERO CRD42019125658。