The association between asthma exacerbation during pregnancy and adverse maternal and child health outcomes have not been investigated appropriately. Our objective was to determine the short- and long-term intergenerational effect of asthma exacerbation in pregnant women with asthma. A population cohort study was conducted using data from the Ontario asthma surveillance system and population-level health administrative data. Asthma exacerbation in pregnant women with asthma was defined as at least one of the following criteria: at least five physician visits, or one emergency department visit or one hospital admission for asthma during pregnancy. Pregnancy complications, adverse perinatal outcomes and early childhood respiratory disorders were identified using International Classification of Disease codes (9th and 10th revisions). The cohort consisted of 103 424 singleton pregnancies in women with asthma. Asthma exacerbation in pregnant women with asthma was associated with higher odds of pre-eclampsia (OR 1.30, 95% CI 1.12–1.51) and pregnancy-induced hypertension (OR 1.17, 95% CI 1.02–1.33); babies had higher odds of low birthweight (OR 1.14, 95% CI 1.00–1.31), preterm birth (OR 1.14, 95% CI 1.01–1.29) and congenital malformations (OR 1.21, 95% CI 1.05–1.39). Children born to women with asthma exacerbation during pregnancy had elevated risk of asthma (OR 1.23, 95% CI 1.13–1.33) and pneumonia (OR 1.12, 95% CI 1.03–1.22) during the first 5 years of life. Asthma exacerbation during pregnancy in women with asthma showed increased risk of pregnancy complications, adverse perinatal outcomes and early childhood respiratory disorders in their children, indicating that appropriate asthma management may reduce the risk of adverse health outcomes. This study shows that women with asthma having asthma exacerbation during pregnancy have increased risk of adverse maternal and child health outcomes. Women with asthma during pregnancy require appropriate asthma management and follow-up. http://bit.ly/2Nh8q61

中文翻译：

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妊娠期哮喘加重对哮喘妇女的影响：一项基于人群的队列研究

怀孕期间哮喘加重与不良母婴健康结局之间的关联尚未得到适当调查。我们的目标是确定哮喘孕妇哮喘发作的短期和长期代际影响。使用安大略哮喘监测系统的数据和人口水平的健康管理数据进行了一项人群队列研究。患有哮喘的孕妇的哮喘恶化定义为以下标准中的至少一项：至少 5 次医生就诊，或 1 次急诊就诊或 1 次怀孕期间因哮喘住院。使用国际疾病分类代码（第 9 次和第 10 次修订版）确定妊娠并发症、不良围产期结局和儿童早期呼吸系统疾病。该队列包括 103 424 名患有哮喘的单胎妊娠妇女。患有哮喘的孕妇的哮喘恶化与先兆子痫（OR 1.30，95% CI 1.12-1.51）和妊娠高血压（OR 1.17，95% CI 1.02-1.33）的几率较高有关；婴儿出现低出生体重 (OR 1.14, 95% CI 1.00–1.31)、早产 (OR 1.14, 95% CI 1.01–1.29) 和先天性畸形 (OR 1.21, 95% CI 1.05–1.39) 的几率更高。怀孕期间哮喘加重的妇女所生的孩子在生命的前 5 年内患哮喘 (OR 1.23, 95% CI 1.13–1.33) 和肺炎 (OR 1.12, 95% CI 1.03–1.22) 的风险升高。患有哮喘的妇女在怀孕期间的哮喘加重表明其子女出现妊娠并发症、不良围产期结局和儿童早期呼吸系统疾病的风险增加，表明适当的哮喘管理可以降低不良健康结果的风险。这项研究表明，患有哮喘的女性在怀孕期间出现哮喘发作，其母婴健康不良结局的风险会增加。怀孕期间患有哮喘的妇女需要适当的哮喘管理和随访。http://bit.ly/2Nh8q61