Population genomics of Klebsiella pneumoniae.,Nature Reviews Microbiology

当前位置： X-MOL 学术 › Nat. Rev. Microbiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Population genomics of Klebsiella pneumoniae.
Nature Reviews Microbiology ( IF 69.2 ) Pub Date : 2020-02-13 , DOI: 10.1038/s41579-019-0315-1
Kelly L Wyres ₁ , Margaret M C Lam ₁ , Kathryn E Holt _{1,

2}

Affiliation

Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections in hospitalized patients. The species is naturally resistant to penicillins, and members of the population often carry acquired resistance to multiple antimicrobials. However, knowledge of K. pneumoniae ecology, population structure or pathogenicity is relatively limited. Over the past decade, K. pneumoniae has emerged as a major clinical and public health threat owing to increasing prevalence of healthcare-associated infections caused by multidrug-resistant strains producing extended-spectrum β-lactamases and/or carbapenemases. A parallel phenomenon of severe community-acquired infections caused by 'hypervirulent' K. pneumoniae has also emerged, associated with strains expressing acquired virulence factors. These distinct clinical concerns have stimulated renewed interest in K. pneumoniae research and particularly the application of genomics. In this Review, we discuss how genomics approaches have advanced our understanding of K. pneumoniae taxonomy, ecology and evolution as well as the diversity and distribution of clinically relevant determinants of pathogenicity and antimicrobial resistance. A deeper understanding of K. pneumoniae population structure and diversity will be important for the proper design and interpretation of experimental studies, for interpreting clinical and public health surveillance data and for the design and implementation of novel control strategies against this important pathogen.

中文翻译：

肺炎克雷伯菌的种群基因组学。

肺炎克雷伯菌是住院患者抗药性机会感染的常见原因。该物种对青霉素具有天然抗性，并且该种群的成员通常对多种抗菌素具有获得性抗性。但是，关于肺炎克雷伯菌的生态学，种群结构或致病性的知识相对有限。在过去的十年中，由于由产生广谱β-内酰胺酶和/或碳青霉烯酶的多药耐药菌株引起的医疗保健相关感染的流行，肺炎克雷伯菌已成为主要的临床和公共卫生威胁。还出现了由“高毒力”肺炎克雷伯菌引起的严重社区获得性感染的平行现象，与表达获得性毒力因子的菌株有关。这些独特的临床问题激发了人们对肺炎克雷伯菌研究特别是基因组学应用的兴趣。在这篇综述中，我们讨论了基因组学方法如何增进我们对肺炎克雷伯菌的分类学，生态学和进化以及致病性和抗菌素耐药性临床相关决定因素的多样性和分布的了解。对肺炎克雷伯菌的种群结构和多样性的更深入了解，对于正确设计和解释实验研究，解释临床和公共卫生监测数据以及针对这种重要病原体的新颖控制策略的设计和实施将具有重要意义。我们讨论了基因组学方法如何增进我们对肺炎克雷伯菌的分类学，生态学和进化以及致病性和抗菌素耐药性临床相关决定因素的多样性和分布的了解。对肺炎克雷伯菌的种群结构和多样性的更深入了解，对于正确设计和解释实验研究，解释临床和公共卫生监测数据以及针对这种重要病原体的新颖控制策略的设计和实施将具有重要意义。我们讨论了基因组学方法如何增进我们对肺炎克雷伯菌的分类学，生态学和进化以及致病性和抗菌素耐药性临床相关决定因素的多样性和分布的了解。对肺炎克雷伯菌的种群结构和多样性的更深入了解，对于正确设计和解释实验研究，解释临床和公共卫生监测数据以及针对这种重要病原体的新颖控制策略的设计和实施将具有重要意义。

更新日期：2020-02-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11