Innovative and rapid antimicrobial susceptibility testing systems.,Nature Reviews Microbiology

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Innovative and rapid antimicrobial susceptibility testing systems.
Nature Reviews Microbiology ( IF 69.2 ) Pub Date : 2020-02-13 , DOI: 10.1038/s41579-020-0327-x
Alex van Belkum ₁ , Carey-Ann D Burnham ₂ , John W A Rossen _{3,

4} , Frederic Mallard ₅ , Olivier Rochas ₆ , William Michael Dunne _{2,

7}

Affiliation

Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid detection and quantification of resistance, combined with antimicrobial stewardship, are key interventions to combat the spread and emergence of AMR. Antimicrobial susceptibility testing (AST) systems are the collective set of diagnostic processes that facilitate the phenotypic and genotypic assessment of AMR and antibiotic susceptibility. Over the past 30 years, only a few high-throughput AST methods have been developed and widely implemented. By contrast, several studies have established proof of principle for various innovative AST methods, including both molecular-based and genome-based methods, which await clinical trials and regulatory review. In this Review, we discuss the current state of AST systems in the broadest technical, translational and implementation-related scope.

中文翻译：

创新和快速的抗菌药物敏感性测试系统。

抗菌素耐药性 (AMR) 是全球人类健康的主要威胁，快速检测和量化耐药性，结合抗菌素管理，是对抗 AMR 传播和出现的关键干预措施。抗菌药物敏感性测试 (AST) 系统是一组有助于对 AMR 和抗生素敏感性进行表型和基因型评估的诊断过程。在过去的 30 年中，只有少数高通量 AST 方法被开发并广泛实施。相比之下，一些研究已经为各种创新的 AST 方法建立了原理证明，包括基于分子和基于基因组的方法，这些方法正在等待临床试验和监管审查。在这篇评论中，我们从最广泛的技术角度讨论了 AST 系统的现状，

更新日期：2020-02-13

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