Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties.,Bioconjugate Chemistry

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Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-02-25 , DOI: 10.1021/acs.bioconjchem.0c00030
Ayan Kumar Barui _{1,

2} , Priya Jhelum ₁ , Susheel Kumar Nethi _{1,

2} , Tapatee Das _{1,

2} , Dwaipayan Bhattacharya ₁ , Vinothkumar B ₁ , Shailaja Karri ₁ , Sumana Chakravarty _{1,

2} , Chitta Ranjan Patra _{1,

2}

Affiliation

Neuritogenesis, a complex process of the sprouting of neurites, plays a vital role in the structural and functional restoration of cerebral ischemia-injured neuronal tissue. Practically, there is no effective long-term treatment strategy for cerebral ischemia in clinical practice to date due to several limitations of conventional therapies, facilitating the urgency to develop new alternative therapeutic approaches. Herein, for the first time we report that pro-angiogenic nanomaterials, zinc oxide nanoflowers (ZONF), exhibit neuritogenic activity by elevating mRNA expression of different neurotrophins, following PI3K/Akt-MAPK/ERK signaling pathways. Further, ZONF administration to global cerebral ischemia-induced Fischer rats shows improved neurobehavior and enhanced synaptic plasticity of neurons via upregulation of Neurabin-2 and NT-3, revealing their neuroprotective activity. Altogether, this study offers the basis for exploitation of angio-neural cross talk of other pro-angiogenic nano/biomaterials for future advancement of alternative treatment strategies for cerebral ischemia, where neuritogenesis and neural repair are highly critical.

中文翻译：

氧化锌纳米花通过中枢神经保护和神经保护特性在脑缺血大鼠模型中的潜在治疗应用。

神经发生是神经突发芽的复杂过程，在脑缺血损伤的神经元组织的结构和功能恢复中起着至关重要的作用。实际上，由于常规疗法的一些局限性，迄今为止在临床实践中，尚无有效的脑缺血长期治疗策略，这促进了开发新的替代治疗方法的紧迫性。在本文中，我们首次报道了沿PI3K / Akt-MAPK / ERK信号通路，促血管生成纳米材料氧化锌纳米花（ZONF）通过提高不同神经营养蛋白的mRNA表达而表现出神经活性。此外，通过对Neurabin-2和NT-3的上调，对整体性脑缺血诱导的Fischer大鼠进行ZONF给药可改善神经行为，增强神经元的突触可塑性，揭示他们的神经保护活性。总而言之，这项研究为利用其他促血管生成纳米/生物材料的血管神经串扰提供了基础，以进一步促进脑缺血的替代治疗策略的发展，其中神经形成和神经修复至关重要。

更新日期：2020-02-26

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