Ischemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation,Annals of Neurology

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Ischemic stroke despite oral anticoagulant therapy in patients with atrial fibrillation
Annals of Neurology ( IF 8.1 ) Pub Date : 2020-02-27 , DOI: 10.1002/ana.25700
David J Seiffge _{1,

2,

3} , Gian Marco De Marchis ₂ , Masatoshi Koga ₄ , Maurizio Paciaroni ₅ , Duncan Wilson ₁ , Manuel Cappellari ₆ , Kosmas Macha Md ₇ , Georgios Tsivgoulis _{8,

9} , Gareth Ambler ₁₀ , Shoji Arihiro ₄ , Leo H Bonati ₂ , Bruno Bonetti ₆ , Bernd Kallmünzer ₇ , Keith W Muir ₁₁ , Paolo Bovi ₆ , Henrik Gensicke _{2,

12} , Manabu Inoue ₄ , Stefan Schwab ₇ , Shadi Yaghi ₁₃ , Martin M Brown ₁ , Philippe Lyrer ₂ , Masahito Takagi ₄ , Monica Acciarrese ₅ , Hans Rolf Jager ₁₄ , Alexandros A Polymeris ₂ , Kazunori Toyoda ₄ , Michele Venti ₅ , Christopher Traenka ₂ , Hiroshi Yamagami ₄ , Andrea Alberti ₅ , Sohei Yoshimura ₄ , Valeria Caso ₅ , Stefan T Engelter _{2,

12} , David J Werring ₁ ,

Affiliation

Stroke Research Center, Department of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology, and the National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Neurology and Stroke Center, Department of Clinical Research, University Hospital of Basel, University of Basel, Basel, Switzerland.
Department of Neurology and Stroke Center, University Hospital of Bern, Bern, Switzerland.
Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Stroke Unit, Department of Neuroscience, University Hospital Integrated Trust of Verona, Verona, Italy.
Department of Neurology, University of Erlangen-Nürnberg, Erlangen, Germany.
Second Department of Neurology, National and Kapodistrian University of Athens School of Medicine, Attikon University Hospital, Athens, Greece.
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN.
Department of Statistical Science, University College London, London, United Kingdom.
Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, United Kingdom.
Neurorehabilitation Unit, University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, University of Basel, Basel, Switzerland.
NYU Langone Health, New York, NY.
Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology, London, United Kingdom.

It is not known whether patients with atrial fibrillation (AF) with ischemic stroke despite oral anticoagulant therapy are at increased risk for further recurrent strokes or how ongoing secondary prevention should be managed.

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