Recent Advances in Total Synthesis of Bioactive Furo[3,2‐b]furanone Natural Products,Asian Journal of Organic Chemistry

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Recent Advances in Total Synthesis of Bioactive Furo[3,2‐b]furanone Natural Products
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-02-13 , DOI: 10.1002/ajoc.201900714
Bilal A. Bhat _{1,

2} , Showkat Rashid _{1,

2} , Saumitra Sengupta ₃ , Goverdhan Mehta ₃

Affiliation

The ubiquitous presence of highly oxygenated furo[3,2‐b]furanone fragments in diverse natural products with wide range of biological activities such as anti‐cancer, anti‐HIV, anti‐microbial activities, etc., has augmented their appeal both for synthetic and medicinal chemistry campaigns. Enticed by their potent biological activities and challenging polycyclic architecture, total synthesis of furo[3,2‐b]furanone natural products has witnessed intense activity in recent years with many notable achievements in the synthesis of structurally embellished family of bioactive metabolites such as plakortones, lactonamycines, schisanartanes, etc. While presenting a comprehensive account of post‐2000 syntheses of these natural products, through strategic and nuanced use of modern tools of organic synthesis, this review also aims to stimulate interest in exploring the diversity space around these natural products for newer applications.

中文翻译：

生物活性呋喃并[3,2-b]呋喃酮天然产物全合成的最新进展

高氧合的呋喃并[3,2- b ]呋喃酮片段广泛存在于具有广泛生物活性（例如抗癌，抗艾滋病毒，抗微生物活性等）的多种天然产物中，从而增强了它们的吸引力。合成化学和药物化学运动。由于其强大的生物活性和具有挑战性的多环结构而着迷，呋喃[3,2- b]呋喃酮天然产物近几年来表现活跃，在合成具有结构修饰的生物活性代谢物家族中有许多显着成就，如普拉克酮，内酰胺类，五氢三art烷等。虽然全面介绍了这些天然产物在2000年后的合成，通过对现代有机合成工具的战略性和细致入微的使用，本综述的目的还在于激发人们对探索这些天然产物周围的多样性空间以用于新应用的兴趣。

更新日期：2020-04-21

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