BACKGROUND Prescription drugs are controlled medicines due to their potential risks of being diverted, misused, and abused. Since the introduction of antiretroviral (ARVs) drugs, HIV is currently regarded as a chronic condition. However, prescription drug diversion, misuse, and abuse might serve as one of the critical barriers for achieving optimal medication adherence among people living with HIV, thereby negatively impacting the HIV care mandate. The primary aim of this scoping review is to gather evidence on the prevalence, practices, risk factors, and motives associated with prescription drug diversion, misuse, and abuse, as well as the evidence on the association between prescription drug diversion, misuse, and abuse with antiretroviral treatment (ART) adherence. METHODS This review will be guided by Arksey and O'Malley's framework as well as recommendations by Levac et al. (Implement Sci 5:69, 2010). We will search the following databases for relevant literature meeting our eligibility criteria: PubMed, Google Scholar, EBSCOhost (Academic Search Complete, MEDLINE, and Newspaper Source), World Health Organization, Science Direct, and Open Access Theses and Dissertations. Studies published within the period of January 1996 to June 2019 are eligible. The included studies should report evidence on the prevalence, practices, risk factors, motives, or association between ART adherence and prescription drug diversion, misuse, and abuse. Thematic analysis will be applied to summarize the review findings. DISCUSSION We anticipate finding a considerable number of research studies on prescription drug diversion, misuse, and abuse among people living with HIV. Our synthesis of this evidence base is intended to serve as guidance for future research studies. The study findings will be disseminated through the traditional academic platforms, such as peer-reviewed publications and presentations at relevant local and international conferences, symposiums, and seminars. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42017074076.

中文翻译：

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艾滋病毒感染者中的处方药转移，滥用和滥用：范围界定审查方案。

背景技术处方药由于其被转移，误用和滥用的潜在风险而成为管制药物。自从引入抗逆转录病毒（ARVs）药物以来，HIV被视为慢性病。但是，处方药的转移，滥用和滥用可能会成为在HIV感染者中实现最佳药物依从性的关键障碍之一，从而对HIV护理规定产生负面影响。范围界定审查的主要目的是收集与处方药转移，滥用和滥用相关的流行，做法，风险因素和动机的证据，以及有关处方药转移，滥用和滥用之间的关联的证据坚持抗逆转录病毒治疗（ART）。方法该评价将在Arksey和O'Malley'的指导下进行 的框架以及Levac等人的建议。（实施科学5:69，2010）。我们将在以下数据库中搜索符合我们资格标准的相关文献：PubMed，Google Scholar，EBSCOhost（学术搜索完成，MEDLINE和报纸来源），世界卫生组织，《科学直接》和开放获取论文和学位论文。在1996年1月至2019年6月期间发表的研究符合资格。纳入的研究应报告关于抗逆转录病毒疗法的依从性与处方药转移，滥用和滥用之间的患病率，实践，危险因素，动机或关联的证据。主题分析将用于总结审查结果。讨论我们期望找到大量有关艾滋病毒感染者中处方药转移，滥用和滥用的研究。我们对此证据基础的综合旨在为将来的研究提供指导。研究结果将通过传统的学术平台进行传播，例如经过同行评审的出版物以及在相关的本地和国际会议，座谈会和研讨会上的演讲。系统审查注册PROSPERO CRD42017074076。