Since the introduction of glyphosate-tolerant genetically-modified plants, the global use of glyphosate has increased dramatically making it the most widely used pesticide on the planet. There is considerable controversy concerning the carcinogenicity of glyphosate with scientists and regulatory authorities involved in the review of glyphosate having markedly different opinions. One key aspect of these opinions is the degree to which glyphosate causes cancer in laboratory animals after lifetime exposure. In this review, twenty-one chronic exposure animal carcinogenicity studies of glyphosate are identified from regulatory documents and reviews; 13 studies are of sufficient quality and detail to be reanalyzed in this review using trend tests, historical control tests and pooled analyses. The analyses identify 37 significant tumor findings in these studies and demonstrate consistency across studies in the same sex/species/strain for many of these tumors. Considering analyses of the individual studies, the consistency of the data across studies, the pooled analyses, the historical control data, non-neoplastic lesions, mechanistic evidence and the associated scientific literature, the tumor increases seen in this review are categorized as to the strength of the evidence that glyphosate causes these cancers. The strongest evidence shows that glyphosate causes hemangiosarcomas, kidney tumors and malignant lymphomas in male CD-1 mice, hemangiomas and malignant lymphomas in female CD-1 mice, hemangiomas in female Swiss albino mice, kidney adenomas, liver adenomas, skin keratoacanthomas and skin basal cell tumors in male Sprague-Dawley rats, adrenal cortical carcinomas in female Sprague-Dawley rats and hepatocellular adenomas and skin keratocanthomas in male Wistar rats.

中文翻译：

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对长期接触啮齿动物致癌性研究中草甘膦动物致癌性数据的综合分析。


自从引入耐草甘膦的转基因植物以来，草甘膦的全球使用量急剧增加，使其成为地球上使用最广泛的农药。关于草甘膦的致癌性存在相当大的争议，参与草甘膦审查的科学家和监管机构的意见截然不同。这些观点的一个关键方面是草甘膦在实验动物终生接触后导致癌症的程度。在本次审查中，从监管文件和审查中确定了 21 项长期接触草甘膦的动物致癌性研究； 13 项研究具有足够的质量和细节，可以在本次综述中使用趋势检验、历史控制检验和汇总分析进行重新分析。分析确定了这些研究中 37 个重要的肿瘤发现，并证明了许多此类肿瘤在相同性别/物种/品系的研究中的一致性。考虑到个别研究的分析、研究间数据的一致性、汇总分析、历史对照数据、非肿瘤性病变、机制证据和相关科学文献，本综述中观察到的肿瘤增加按强度进行分类草甘膦导致这些癌症的证据。最有力的证据表明，草甘膦可引起雄性CD-1小鼠的血管肉瘤、肾肿瘤和恶性淋巴瘤、雌性CD-1小鼠的血管瘤和恶性淋巴瘤、雌性瑞士白化小鼠的血管瘤、肾腺瘤、肝腺瘤、皮肤角化棘皮瘤和皮肤基底细胞瘤。雄性 Sprague-Dawley 大鼠的细胞肿瘤、雌性 Sprague-Dawley 大鼠的肾上腺皮质癌以及雄性 Wistar 大鼠的肝细胞腺瘤和皮肤角化棘皮瘤。