Macrocycle-Based Polymer Nanocapsules for Hypoxia-Responsive Payload Delivery,ACS Materials Letters

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Macrocycle-Based Polymer Nanocapsules for Hypoxia-Responsive Payload Delivery
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-02-14 , DOI: 10.1021/acsmaterialslett.0c00002
Chen Sun ₁ , Ludan Yue ₁ , Qian Cheng ₁ , Ziyi Wang ₁ , Ruibing Wang ₁

Affiliation

Hypoxia is a typical hallmark in several disease conditions, particularly in solid tumors. Thus, hypoxia-responsive nanocarriers that may specifically deliver and release payload under hypoxic conditions have been highly sought after, for precision medicine. Herein, we report the first hypoxia-responsive, covalently self-assembled polymer nanocapsules (NCs), formed via directly crosslinking perhydroxycucurbit[6]uril with a ditopic, hypoxia-responsive azobenzene derivative (AZO). Because of the presence of macrocyclic cucurbit[6]uril, the hypoxia-responsive nanocapsules (AZO-NCs) allowed modular, noncovalent surface functionalization. As a proof-of-concept, folate-functionalized AZO-NCs exhibited targeted payload delivery into cancer cells, and more importantly, hypoxia-responsive payload release was validated both in vitro and in vivo.

中文翻译：

基于大环的聚合物纳米胶囊用于缺氧响应有效载荷递送

缺氧是几种疾病的典型特征，尤其是在实体瘤中。因此，对于精密医学，已经强烈寻求可以在低氧条件下特异性递送和释放有效载荷的低氧响应性纳米载体。在这里，我们报告了第一个缺氧反应性，共价自组装的聚合物纳米胶囊（NCs），是通过将全羟基葫芦[6] uril与对位，缺氧反应性的偶氮苯衍生物（AZO）直接交联而形成的。由于大环葫芦[6] uril的存在，缺氧响应纳米胶囊（AZO-NCs）允许模块化，非共价的表面功能化。作为概念验证，叶酸官能化的AZO-NCs展示了靶向有效载荷向癌细胞的传递，更重要的是，在体外和体内均验证了低氧应答有效载荷的释放。

更新日期：2020-02-14

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