Asymmetric Epoxidation of α,β‐Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)‐3,4‐Diaminopyrrolidine Derived N4‐Ligands with Camphorsulfonyl Sidearms,Asian Journal of Organic Chemistry

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Asymmetric Epoxidation of α,β‐Unsaturated Ketones Catalyzed by Chiral Iron Complexes of (R,R)‐3,4‐Diaminopyrrolidine Derived N4‐Ligands with Camphorsulfonyl Sidearms
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-04 , DOI: 10.1002/ajoc.202000070
Yuanfeng Li ₁ , Yuecheng Zhang _{1,

2} , Hong‐Yu Zhang ₁ , Ya‐Ping Han ₁ , Jiquan Zhao ₁

Affiliation

Three (R,R)‐3,4‐diaminopyrrolidine‐based chiral N₄ ligands and corresponding iron complexes were synthesized. The complexes were applied to the asymmetric epoxidation of various α,β‐unsaturated ketones with H₂O₂ as an oxidant and carboxylic acid as auxiliary. Good to excellent enantioselectivity (up to 97%) was achieved in the case of 2,2‐dimethylbutyric acid as an auxiliary.

中文翻译：

（R，R）-3,4-二氨基吡咯烷衍生的N4-配体的手性铁配合物与樟脑磺酰基侧臂催化α，β-不饱和酮的不对称环氧化

合成了三个（R，R）-3,4-二氨基吡咯烷基手性N ₄配体和相应的铁配合物。该配合物以H ₂ O ₂为氧化剂，羧酸为助剂，用于各种α，β-不饱和酮的不对称环氧化。以2,2-二甲基丁酸为辅助剂时，对映体选择性良好（高达97％）。

更新日期：2020-04-21

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