Few studies have focused on metabolite diffusion in the human brain using ¹H‐MRS due to significant technical challenges. Moreover, such studies have required lengthy acquisition times and are therefore impractical to implement clinically. By first characterizing and then minimizing the effects of linear and oscillating eddy currents, which arise from the diffusion gradients, and by implementing phase‐cycle and slice‐order strategies, as well as introducing a new phase‐alignment methodology, we report a method that allows data acquisition requiring 20 seconds per spectrum. This remained feasible, even for b‐values >8000 s/mm², with a rapid acquisition diffusion MRS methodology. It has allowed the nonlinear characterization of signal intensity with multiple b‐values, and has improved the measurement of rotationally invariant diffusion parameters via six‐direction, six b‐value diffusion tensor spectroscopy (DTS) in 12 minutes at 4.7 T. The shorter DTS acquisition will enable its application to white matter regions not aligned with the gradients and permit clinical studies in a feasible time.

中文翻译：

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人脑代谢物的快速采集扩散磁共振波谱

由于重大的技术挑战，很少有研究关注使用^{1 H-MRS 在人脑中的代谢物扩散。}此外，此类研究需要较长的采集时间，因此在临床上实施是不切实际的。通过首先表征然后最小化由扩散梯度引起的线性和振荡涡流的影响，并通过实施相位周期和切片顺序策略，以及引入新的相位对齐方法，我们报告了一种方法允许每个光谱需要 20 秒的数据采集。这仍然是可行的，即使b值>8000 s/mm ²，使用快速采集扩散 MRS 方法。它允许对信号强度进行非线性表征b 值，并通过六方向六b值扩散张量光谱 (DTS) 在 4.7 T 下在 12 分钟内改进了旋转不变扩散参数的测量。较短的 DTS 采集将使其能够应用于未对齐的白质区域梯度并允许在可行的时间内进行临床研究。