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Novel Schiff bases–based thiophenes: Design, synthesis and biological evaluation
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2020-02-11 , DOI: 10.1002/jccs.201900388
Divyaraj Puthran 1, 2 , Boja Poojary 1 , Soukhyarani G. Nayak 1 , Nikil Purushotham 1 , Manjunath Bhat 3 , Hemant Hedge 4
Affiliation  

2‐amino‐5‐(3‐fluoro‐4‐methoxyphenyl)thiophene‐3‐carbonitrile derivatives have been synthesized from 1‐(3‐fluoro‐4‐methoxyphenyl)ethanone, malononitrile, mild base, and sulfur powder using the Gewald method through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR, and mass spectral data, and then synthesized compounds were screened for their in vitro antimicrobial activity. Among them, derivatives 3b (thiphene), 3f (pyrazole), and 3d (halogen) showed good activity and remaining derivatives exhibited moderate activity.

中文翻译:

基于新型席夫碱的噻吩:设计,合成和生物学评估

使用Gewald方法从1-(3-氟-4-甲氧基苯基)乙酮,丙二腈,温和碱和硫粉中合成了2-氨基-5-(3-氟-4-甲氧基苯基)噻吩-3-腈衍生物通过多步反应序列 根据元素分析,IR,1 H NMR,13 C NMR和质谱数据建立新合成化合物的结构,然后筛选合成化合物的体外抗菌活性。其中,衍生物3b(噻吩),3f(吡唑)和3d(卤素)显示出良好的活性,其余的衍生物显示出中等的活性。
更新日期:2020-02-11
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