BACKGROUND Glomus jugulare tumors (GJTs) are uncommon and locally disruptive tumors that usually arise within the jugular foramen of the temporal bone. Surgery was the treatment of choice up until recently. In the last decades, however, radiosurgery has surfaced as a promising alternative treatment by providing excellent tumor control with low risk of cranial nerve injuries. Our aim was to examine the results of radiosurgery specifically, linear accelerator stereotactic radiosurgery (LINAC SRS) for GJT treatment. We hypothesized that radiosurgery will reduce the size of the tumor and improve neurological symptoms. DESIGN AND METHOD Between January 1, 1994 and December 31, 2013, 30 patients with GJTs were treated in Sheba Medical Center using LINAC SRS treatment. Comprehensive clinical follow-up was available for 23 patients. Sixteen patients were female and seven males with a median age of 64 years, with a range of 18-87 years. In 19 of the patients, LINAC SRS was the primary treatment, whereas in the remaining four cases, surgery or embolization preceded radiosurgery. The median treated dose to tumor margin was 14 Gy (range 12-27 Gy), and the median tumor volume before treatment was 5 ml (range 0.5-15 ml). RESULTS Following the LINAC SRS treatment, 14 of 23 patients (60%) showed improvement of previous neurological deficits, nine patients (40%) remained unchanged. At the end of a follow-up, tumor reduction was seen in 13 patients and a stable volume in eight (91% tumor control rate). Two cases of tumor progression were noted. Three patients (13%) had post- SRS complications during the follow-up, two of which achieved tumor control, while in one the tumor advanced. CONCLUSIONS LINAC SRS is a practical treatment option for GJTs, with a high rate of tumor control and satisfactory neurological improvement.

中文翻译：

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颈静脉球肿瘤的 LINAC 放射外科手术：回顾性 - 23 名患者的队列研究。

背景 颈静脉球肿瘤 (GJT) 是罕见的局部破坏性肿瘤，通常发生在颞骨的颈静脉孔内。直到最近，手术还是首选的治疗方法。然而，在过去的几十年中，放射外科通过提供出色的肿瘤控制和低颅神经损伤风险而成为一种有前途的替代治疗方法。我们的目的是检查放射外科手术的结果，特别是用于 GJT 治疗的直线加速器立体定向放射外科手术 (LINAC SRS)。我们假设放射外科手术会缩小肿瘤的大小并改善神经系统症状。设计与方法 1994 年 1 月 1 日至 2013 年 12 月 31 日期间，30 名 GJT 患者在 Sheba 医疗中心接受了 LINAC SRS 治疗。对 23 名患者进行了全面的临床随访。16 名患者为女性，7 名男性，中位年龄为 64 岁，范围为 18-87 岁。在 19 名患者中，LINAC SRS 是主要治疗方法，而在其余 4 名患者中，手术或栓塞术先于放射外科治疗。肿瘤边缘的中位治疗剂量为14 Gy（范围12-27 Gy），治疗前的中位肿瘤体积为5 ml（范围0.5-15 ml）。结果 LINAC SRS 治疗后，23 名患者中有 14 名 (60%) 显示先前的神经功能缺损有所改善，9 名患者 (40%) 保持不变。在随访结束时，13 名患者的肿瘤缩小，8 名患者的体积稳定（91% 的肿瘤控制率）。注意到两例肿瘤进展。3 名患者 (13%) 在随访期间出现 SRS 后并发症，其中 2 名达到肿瘤控制，1 名肿瘤进展。