BACKGROUND Histologic healing is emerging as a new therapeutic goal in both routine practice and clinical trials in ulcerative colitis (UC). However, it requires repeated endoscopies and biopsies. Faecal calprotectin is a non-invasive marker of mucosal healing (endoscopic and histologic healing). AIM To conduct a systematic review to clarify the correlation between faecal calprotectin levels and histologic activity in UC patients. METHODS We searched PubMed/MEDLINE, EMBASE and Web of Science through September 2019 to identify studies in patients with confirmed diagnosis of UC, reporting the correlation between faecal calprotectin levels and histologic analysis. RESULTS Twelve studies enrolling 1168 patients were included in the final review. Histologic remission was defined according to nonvalidated scores in five articles and using partially validated scores in seven articles. Faecal calprotectin values were measured in 6 of 12 studies (50%) with the same kit, while the remaining six studies adopted individually different kits. A clear correlation between faecal calprotectin levels and histology was showed in all included studies. Eleven different faecal calprotectin cut-off points were identified to distinguish histological remission from histological activity, ranging from 40.5 to 250 μg/g. CONCLUSIONS Faecal calprotectin can be used to predict histologic remission in patients with UC, but the cut-off level varies across studies, according to the test used to measure this biomarker and according to the definition of histologic remission. Larger prospective studies using validated histologic indexes are needed to identify a globally accepted faecal calprotectin cut-off level to discriminate between histologic remission and histologically active disease.

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综述文章：溃疡性结肠炎的粪便钙卫蛋白和组织学缓解。

背景技术在溃疡性结肠炎（UC）的常规实践和临床试验中，组织学愈合正在成为新的治疗目标。但是，这需要反复进行内窥镜检查和活检。粪便钙卫蛋白是粘膜愈合（内镜和组织学愈合）的非侵入性标记。目的进行系统评价，以明确UC患者粪便钙卫蛋白水平与组织学活性之间的关系。方法我们搜索了截至2019年9月的PubMed / MEDLINE，EMBASE和Web of Science，以鉴定对确诊为UC的患者进行的研究，报告粪便钙卫蛋白水平与组织学分析之间的相关性。结果12项纳入1168例患者的研究纳入了最终评价。组织学缓解是根据五篇文章中未经验证的评分以及七篇文章中使用部分经过验证的评分定义的。粪便钙卫蛋白值在12份研究中的6份（50％）中使用相同的试剂盒测量，而其余6份研究采用单独的不同试剂盒。所有纳入的研究均显示粪便钙卫蛋白水平与组织学之间存在明显的相关性。确定了11个不同的粪便钙卫蛋白截止点，以区分组织学缓解与组织学活性，范围为40.5至250μg/ g。结论粪便钙卫蛋白可用于预测UC患者的组织学缓解，但根据测量该生物标志物的试验和组织学缓解的定义，不同研究的临界水平有所不同。