Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder.,Translational Psychiatry

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Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder.
Translational Psychiatry ( IF 5.8 ) Pub Date : 2020-02-12 , DOI: 10.1038/s41398-020-0740-y
Xiaojie Guo _{1,

2} , Dongren Yao _{3,

4} , Qingjiu Cao _{1,

2} , Lu Liu _{1,

2} , Qihua Zhao _{1,

2} , Hui Li _{1,

2} , Fang Huang _{1,

2} , Yanfei Wang _{1,

2} , Qiujin Qian _{1,

2} , Yufeng Wang _{1,

2} , Vince D Calhoun ₅ , Stuart J Johnstone ₆ , Jing Sui _{3,

5,

7} , Li Sun _{1,

2}

Affiliation

Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood, with a shift of symptoms including less hyperactivity/impulsivity and more co-morbidity of affective disorders in ADHDadult. Many studies have questioned the stability in diagnosing of ADHD from childhood to adulthood, and the shared and distinct aberrant functional connectivities (FCs) between ADHDchild and ADHDadult remain unidentified. We aim to explore shared and distinct FC patterns in ADHDchild and ADHDadult, and further investigated the cross-cohort predictability using the identified FCs. After investigating the ADHD-discriminative FCs from healthy controls (HCs) in both child (34 ADHDchild, 28 HCs) and adult (112 ADHDadult,77 HCs) cohorts, we identified both shared and distinct aberrant FC patterns between cohorts and their association with clinical symptoms. Moreover, the cross-cohort predictability using the identified FCs were tested. The ADHD-HC classification accuracies were 84.4% and 81.0% for children and male adults, respectively. The ADHD-discriminative FCs shared in children and adults lie in the intra-network within default mode network (DMN) and the inter-network between DMN and ventral attention network, positively correlated with total scores of ADHD symptoms. Particularly, inter-network FC between somatomotor network and dorsal attention network was uniquely impaired in ADHDchild, positively correlated with hyperactivity index; whereas the aberrant inter-network FC between DMN and limbic network exhibited more adult-specific ADHD dysfunction. And their cross-cohort predictions were 70.4% and 75.6% between each other. This work provided imaging evidence for symptomatic changes and pathophysiological continuity in ADHD from childhood to adulthood, suggesting that FCs may serve as potential biomarkers for ADHD diagnosis.

中文翻译：

患有注意力缺陷/多动障碍的儿童和成人的共享和独特的休息功能连接。

注意缺陷/多动障碍（ADHD）通常持续到成年期，症状转移包括ADHD成人的少动/冲动和情感障碍的更多合并症。许多研究质疑从儿童期到成年期多动症的诊断稳定性，而且多动症儿童和多动症成年人之间共享的和独特的异常功能连接性（FC）仍然不确定。我们旨在探索ADHDchild和ADHDadult中共享和独特的FC模式，并使用已确定的FC进一步研究跨队列的可预测性。在调查了儿童（34名ADHD儿童，28名HCs）和成人（112名ADHDadult，77名HCs）队列中来自健康对照（HCs）的ADHD区分性FC后，我们确定了队列之间共享且独特的异常FC模式及其与临床的关联症状。此外，测试了使用识别出的功能界别的跨队列可预测性。儿童和男性成年人的ADHD-HC分类准确度分别为84.4％和81.0％。在儿童和成人中共享的多动症区分性FC位于默认模式网络（DMN）内的网络内以及DMN与腹侧注意网络之间的网络内，与多动症症状的总分呈正相关。尤其是，ADHDchild中体动网络与背侧注意网络之间的网络间FC受到了独特的损害，与多动指数呈正相关。而DMN和边缘网络之间的异常网络间FC表现出更多的成人特异性ADHD功能障碍。他们之间的跨队列预测之间分别为70.4％和75.6％。

更新日期：2020-02-12

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