Radiotracer Development for Bacterial Imaging.,Journal of Medicinal Chemistry

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Radiotracer Development for Bacterial Imaging.
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2020-02-12 , DOI: 10.1021/acs.jmedchem.9b01623
Filipa Mota _{1,

2,

3} , Alvaro A Ordonez _{1,

2,

3} , George Firth ₄ , Camilo A Ruiz-Bedoya _{1,

2,

3} , Michelle T Ma ₄ , Sanjay K Jain _{1,

2,

3}

Affiliation

Bacterial infections remain a major threat to humanity and are a leading cause of death and disability. Antimicrobial resistance has been declared as one of the top ten threats to human health by the World Health Organization, and new technologies are urgently needed for the early diagnosis and monitoring of deep-seated and complicated infections in hospitalized patients. This review summarizes the radiotracers as applied to imaging of bacterial infections. We summarize the recent progress in the development of pathogen-specific imaging and the application of radiotracers in understanding drug pharmacokinetics as well as the local biology at the infection sites. We also highlight the opportunities for medicinal chemists in radiotracer development for bacterial infections, with an emphasis on target selection and radiosynthetic approaches. Imaging of infections is an emerging field. Beyond clinical applications, these technologies could provide unique insights into disease pathogenesis and expedite bench-to-bedside translation of new therapeutics.

中文翻译：

用于细菌成像的Radiotracer开发。

细菌感染仍然是对人类的主要威胁，并且是导致死亡和致残的主要原因。世界卫生组织已宣布抗菌素耐药性是对人类健康的十大威胁之一，并且迫切需要新技术来早期诊断和监测住院患者的深层和复杂感染。这篇综述总结了放射性示踪剂在细菌感染成像中的应用。我们总结了病原体特异性成像的发展和放射性示踪剂在了解药物药代动力学以及感染部位的局部生物学方面的最新进展。我们还将重点介绍药物化学家在放射性示踪剂开发中用于细菌感染的机会，重点是靶标的选择和放射性合成方法。感染的成像是一个新兴领域。除了临床应用之外，这些技术还可以提供对疾病发病机理的独特见解，并加快新疗法的从台到床的转换。

更新日期：2020-02-23

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