BACKGROUND Alcohol use is associated with an increased risk of completed suicide, but it is unclear whether past suicidality affects the course of alcohol use disorder (AUD). We examined whether a history of suicidal ideation or attempts is associated with treatment response in individuals with AUD. METHODS 146 participants underwent inpatient detoxification and residential treatment for AUD. Reductions in craving during treatment were used as an index of treatment response. Participants were assessed for history of suicidality using the Columbia-Suicide Severity Rating Scale and divided into three groups: no history of suicidal ideation or attempts (N = 76), history of suicidal ideation without attempts (N = 50), and history of suicide attempts (N = 20). Alcohol craving was measured weekly during treatment using the Penn Alcohol Craving Scale and compared across groups. RESULTS Individuals with a history of suicide attempts showed higher levels of craving throughout treatment compared to those without a history of suicidality. Associations between past suicide attempts and craving remained significant after adjusting for age, sex, alcohol use disorder severity, comorbid psychopathology, and benzodiazepine treatment. Participants in all groups had significant reductions in alcohol craving by the end of treatment. CONCLUSIONS Our findings suggest that a history of suicide attempts is associated with higher levels of craving throughout inpatient treatment for AUD. These results support current guidelines on assessing suicidal ideation in patients with substance use disorders.

中文翻译：

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酒精使用障碍住院治疗期间的自杀和酒精渴望轨迹的历史。

背景技术饮酒与完全自杀的风险增加有关，但是尚不清楚过去的自杀行为是否影响饮酒障碍（AUD）的病程。我们检查了自杀意念或尝试的历史是否与AUD患者的治疗反应相关。方法146名参与者接受了澳元的住院排毒和住院治疗。治疗期间渴望的减少被用作治疗反应的指标。使用哥伦比亚自杀严重程度等级量表对参与者的自杀史进行评估，并将其分为三组：无自杀意念或未谋杀史（N = 76），无自杀意念和未谋杀史（N = 50）以及自杀史尝试（N = 20）。在治疗期间，每周使用Penn酒精渴望量表测量酒精渴望，并在各组之间进行比较。结果与没有自杀史的人相比，有自杀未遂史的人在整个治疗过程中表现出更高的渴望程度。在调整了年龄，性别，饮酒障碍的严重程度，合并症的心理病理学和苯二氮卓治疗后，过去自杀未遂与渴望之间的联系仍然很明显。到治疗结束时，所有组的参与者对酒精的渴求都有明显减少。结论我们的研究结果表明，在澳大利亚住院期间，自杀未遂史与更高的渴望程度有关。这些结果支持当前有关评估物质滥用障碍患者自杀意念的指南。