Polymers have been shown to have viable applications in the biomedical field, from controlled drug delivery systems to biological implants. The preparation and processing of polymers into bio-systems have nevertheless encountered some technical challenges in part customization and adverse effects to the human body functions and recovery. This study proposes the utilization of 3D printing technology and supercritical carbon dioxide (scCO₂) processing to deliver a drug-impregnated polymeric material system which can be engineered and tuned to suit a particular implantation procedure and dramatically improve patient outcomes. In this work, an acrylate-based polymer is 3D-printed using stereolithography, then impregnated with flurbiprofen drug using scCO₂. Drug loading above 24 % by mass is achievable under the tested conditions. The correlation of drug loading and material surface roughness with different process parameters, including 3D printing layer thickness, scCO₂ processing temperature, pressure and treatment time, are investigated and empirically modeled using the linear regression methods.

聚合物已经显示出在生物医学领域中可行的应用，从受控的药物输送系统到生物植入物。然而，将聚合物制备和加工成生物系统在零件定制以及对人体功能和恢复的不利影响方面遇到了一些技术挑战。这项研究提出利用3D打印技术和超临界二氧化碳（scCO ₂）处理技术来提供一种药物浸渍的聚合物材料系统，该系统可以进行工程设计和调整以适合特定的植入程序并显着改善患者的治疗效果。在这项工作中，使用立体光刻技术对丙烯酸酯类聚合物进行3D打印，然后使用scCO ₂将氟比洛芬药物浸渍。在测试条件下，药物载量可达到24％以上。使用线性回归方法研究了药物负载和材料表面粗糙度与不同工艺参数（包括3D打印层厚度，scCO ₂加工温度，压力和处理时间）的相关性，并进行了经验建模。