The S100 family of proteins contains 25 known members that share a high degree of sequence and structural similarity. However, only a limited number of family members have been characterized in depth, and the roles of other members are likely undervalued. Their importance should not be underestimated however, as S100 family members function to regulate a diverse array of cellular processes including proliferation, differentiation, inflammation, migration and/or invasion, apoptosis, Ca2+ homeostasis, and energy metabolism. Here we detail S100 target protein interactions that underpin the mechanistic basis to their function, and discuss potential intervention strategies targeting S100 proteins in both preclinical and clinical situations.

中文翻译：

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S100蛋白在健康和疾病中的作用。

S100蛋白质家族包含25个已知成员，它们具有高度的序列和结构相似性。但是，只有数量有限的家庭成员得到了深入的描述，其他成员的作用可能被低估了。然而，它们的重要性不容小under，因为S100家族成员可调节多种细胞过程，包括增殖，分化，炎症，迁移和/或侵袭，细胞凋亡，Ca2 +稳态和能量代谢。在这里，我们详细介绍了支撑其功能基础的S100靶蛋白相互作用，并讨论了在临床前和临床情况下针对S100蛋白的潜在干预策略。