Abstract In this work, flower-like bimetallic (Au@Pt) nanoparticles were synthesized by using Carica papaya leaf extract. The optical, structural, and functional properties have been investigated. The UV–vis spectra inferred the formation of bimetallic nanoparticles with highly ordered crystalline structure as revealed by X-ray diffraction analysis. The TEM micrography revealed flower-like bimetallic nanoparticles of 150 ± 1.02 nm. The cytotoxicity of bimetallic nanoparticles was confirmed against MCF-7 breast cancer cells, which indicates their anti-proliferative effect (IC50 value − 120 ± 2.32 µg mL−1). The developed flower-like bimetallic nanoparticles also displayed anti-migration effect by wound healing assay, making it sensibly valuable for cancer chemotherapy.

中文翻译：

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花状双金属（Au@Pt）纳米粒子的抗增殖和抗迁移作用

摘要 在这项工作中，利用番木瓜叶提取物合成了花状双金属（Au@Pt）纳米颗粒。已经研究了光学、结构和功能特性。紫外-可见光谱推断形成了具有高度有序晶体结构的双金属纳米粒子，如 X 射线衍射分析所示。TEM 显微照片显示 150 ± 1.02 nm 的花状双金属纳米粒子。双金属纳米颗粒对 MCF-7 乳腺癌细胞的细胞毒性得到证实，这表明它们具有抗增殖作用（IC50 值 - 120 ± 2.32 µg mL-1）。开发的花状双金属纳米粒子还通过伤口愈合试验显示出抗迁移作用，使其对癌症化疗具有重要意义。