Intracranial self-stimulation (ICSS) of the medial forebrain bundle is an effective treatment to facilitate memory. Performance in both explicit and implicit memory tasks has been improved by ICSS, and this treatment has even been capable of recovering loss of memory function due to lesions or old age. Several neurochemical systems have been studied in regard to their role in ICSS effects on memory, however the possible involvement of the orexinergic system in this facilitation has yet to be explored. The present study aims to examine the relationship between the OX1R and the facilitative effects of ICSS on two different types of memory tasks, both carried out in the Morris Water Maze: spatial and visual discrimination. Results show that the OX1R blockade, by intraventricular administration of SB-334867, partially negates the facilitating effect of ICSS on spatial memory, whereas it hinders ICSS facilitation of the discrimination task. However, ICSS treatment was capable of compensating for the severe detrimental effects of OX1R blockade on both memory paradigms. These results suggest different levels of involvement of the orexinergic system in the facilitation of memory by ICSS, depending on the memory task.

中文翻译：

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Orexin-1受体阻滞通过颅内自我刺激差异性地影响空间和视觉辨别力的记忆促进。

内侧前脑束的颅内自我刺激（ICSS）是促进记忆的有效方法。ICSS改善了显式和隐式记忆任务的性能，这种治疗甚至能够恢复由于病变或衰老引起的记忆功能丧失。已经研究了几种神经化学系统在ICSS对记忆的影响中所起的作用，但是，尚未探究食欲神经系统是否可能参与这种促进作用。本研究旨在研究O​​X1R和ICSS对两种不同类型的记忆任务的促进作用之间的关系，这两种任务均在莫里斯水迷宫中进行：空间和视觉辨别。结果表明，通过脑室内给药SB-334867可以阻断OX1R，在一定程度上抵消了ICSS对空间记忆的促进作用，而阻碍了ICSS对歧视任务的促进。但是，ICSS治疗能够补偿OX1R阻滞对两种记忆模式的严重不利影响。这些结果表明，取决于记忆任务，食欲神经系统参与ICSS促进记忆的程度不同。