Both embryo-derived (ESC) and induced pluripotent stem cell (iPSC) lines have been established in rabbit. They exhibit the essential characteristics of primed pluripotency. In this review, we described their characteristic features at both molecular and functional levels. We also described the attempts to reprogram rabbit pluripotent stem cells (rbPSCs) toward the naive state of pluripotency using methods established previously to capture this state in rodents and primates. In the last section, we described and discussed our current knowledge of rabbit embryo development pertaining to the mechanisms of early lineage segregation. We argued that the molecular signature of naive-state pluripotency differs between mice and rabbits. We finally discussed some of the key issues to be addressed for capturing the naive state in rbPSCs, including the generation of embryo/PSC chimeras.

中文翻译：

---

胚胎来源的和诱导的多能干细胞：在兔中实现幼稚的多能性和嵌合能力。

兔来源的胚胎干细胞（ESC）和诱导性多能干细胞（iPSC）系均已建立。它们表现出引发的多能性的基本特征。在这篇综述中，我们描述了它们在分子和功能水平上的特征。我们还描述了使用以前建立的在啮齿动物和灵长类动物中捕获这种状态的方法，将兔多能干细胞（rbPSC）重新编程为多能性的幼稚状态的尝试。在最后一部分中，我们描述和讨论了我们当前关于兔胚胎发育的知识，这些知识与早期谱系分离的机制有关。我们认为，幼稚多能性的分子标记在小鼠和兔子之间是不同的。最后，我们讨论了在rbPSC中捕获幼稚状态需要解决的一些关键问题，