Epidural electrical spinal stimulation can facilitate recovery of volitional motor control in individuals that have been completely paralyzed for more than a year. We recently reported a novel neuromodulation method named Dynamic Stimulation (DS), which short-lastingly increased spinal excitability and generated a robust modulation of locomotor networks in fully-anesthetized intact adult rats. In the present study, we applied repetitive DS patterns to four lumbosacral segments acutely after a contusive injury at lumbar level. Repetitive DS delivery restored the spinally-evoked motor EMG responses that were previously suppressed by a calibrated spinal cord contusion. Sham experiments without DS delivery did not allow any spontaneous recovery. Thus, DS uniquely provides the potential for a greater long-term functional recovery after paralysis.

中文翻译：

---

严重的脊髓损伤后，急性神经调节可恢复脊髓诱导的运动反应。

硬膜外电刺激可以使完全瘫痪超过一年的个体恢复自主运动控制。我们最近报道了一种称为动态刺激（DS）的新型神经调节方法，该方法可在完全麻醉的完整成年大鼠中短期增加脊髓的兴奋性并产生强烈的运动网络调节。在本研究中，我们在腰部挫伤性损伤后急性地对四个腰s段应用了重复性DS模式。重复的DS递送恢复了脊髓诱发的运动肌电图反应，该反应先前被校准的脊髓挫伤所抑制。没有DS递送的假实验不允许任何自发恢复。因此，DS独特地为瘫痪后的长期功能恢复提供了潜力。