Inflammation and activation of the immune system are key molecular and cellular events in the pathogenesis of cardiovascular diseases, including atherosclerosis, hypertension-induced target-organ damage, and abdominal aortic aneurysm. Angiotensin II (Ang-II) is the main effector peptide hormone of the renin-angiotensin system. Beyond its role as a potent vasoconstrictor and regulator of blood pressure and fluid homeostasis, Ang-II is intimately involved in the development of vascular lesions in cardiovascular diseases through the activation of different immune cells. The migration of leukocytes from circulation to the arterial subendothelial space is a crucial immune response in lesion development that is mediated through a sequential and coordinated cascade of leukocyte-endothelial cell adhesive interactions involving an array of cell adhesion molecules present on target leukocytes and endothelial cells and the generation and release of chemoattractants that activate and guide leukocytes to sites of emigration. In this review, we outline the key events of Ang-II participation in the leukocyte recruitment cascade, the underlying mechanisms implicated, and the corresponding redox-signaling pathways. We also address the use of inhibitor drugs targeting the effects of Ang-II in the context of leukocyte infiltration in these cardiovascular pathologies, and examine the clinical data supporting the relevance of blocking Ang-II-induced vascular inflammation.

中文翻译：

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血管紧张素II和白细胞运输：旧血管介导物的新见解。氧化还原信号通路的作用。

免疫系统的炎症和激活是心血管疾病发病机理中的关键分子和细胞事件，包括动脉粥样硬化，高血压引起的靶器官损伤和腹主动脉瘤。血管紧张素II（Ang-II）是肾素-血管紧张素系统的主要效应肽激素。Ang-II除了作为有效的血管收缩剂和血压及液体稳态的调节剂以外，还通过激活不同的免疫细胞密切参与心血管疾病血管病变的发展。白细胞从循环系统向动脉内皮下空间的迁移是病变发展中的关键免疫反应，其通过白细胞-内皮细胞粘附相互作用的顺序和协调级联介导，涉及靶白细胞和内皮细胞上存在的一系列细胞粘附分子。趋化因子的产生和释放，趋化因子激活并引导白细胞迁移。在这篇综述中，我们概述了Ang-II参与白细胞募集级联的关键事件，潜在的潜在机制以及相应的氧化还原信号通路。我们还研究了在这些心血管疾病中白细胞浸润的情况下针对Ang-II作用的抑制剂药物的使用，