Despite its potential to improve metabolic health outcomes, longitudinal physical activity (PA) patterns and their association with cardiometabolic disease among people living with HIV (PLWH) have not been well characterized. We investigated this relationship among PLWH in the Centers for AIDS Research Network of Integrated Clinical Systems with at least one PA self-report between 2008 and 2015. The 4-item Lipid Research Clinics PA instrument was used to categorize habitual PA levels as: Very Low, Low, Moderate, or High. We analyzed demographic differences in PA patterns. Multivariable generalized estimating equation regression models were fit to assess longitudinal associations of PA with blood pressure, lipid, and glucose levels. Logistic regression modeling was used to assess the odds of being diagnosed with obesity, cardiovascular disease (CVD), cerebrovascular disease, hypertension, diabetes, or multimorbidity. A total of 40,462 unique PA assessments were provided by 11,719 participants. Only 13% of PLWH reported High PA, while 68% reported Very Low/Low PA at baseline and did not increase PA levels during the study period. Compared to those reporting High PA, participants with Very Low PA had almost 2-fold increased risk for CVD. Very Low PA was also associated with several risk factors associated with CVD, most notably elevated triglycerides (odds ratio 25.4), obesity (odds ratio 1.9), hypertension (odds ratio 1.4), and diabetes (odds ratio 2.3; all p < 0.01). Low levels of PA over time among PLWH are associated with increased cardiometabolic disease risk.

中文翻译：

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2008-2015 年美国艾滋病毒感染者的体力活动趋势和代谢健康结果。


尽管其具有改善代谢健康结果的潜力，但艾滋病毒感染者（PLWH）的纵向体力活动（PA）模式及其与心脏代谢疾病的关系尚未得到很好的表征。我们在 2008 年至 2015 年间至少有一份 PA 自我报告，调查了艾滋病研究中心综合临床系统网络中 PLWH 之间的这种关系。4 项脂质研究诊所 PA 仪器用于将习惯性 PA 水平分类为： 极低、低、中或高。我们分析了 PA 模式的人口差异。多变量广义估计方程回归模型适合评估 PA 与血压、血脂和血糖水平的纵向关联。 Logistic 回归模型用于评估被诊断患有肥胖、心血管疾病 (CVD)、脑血管疾病、高血压、糖尿病或多病的几率。 11,719 名参与者总共提供了 40,462 份独特的 PA 评估。只有 13% 的 PLWH 报告高 PA，而 68% 的患者报告基线 PA 极低/低，并且在研究期间没有增加 PA 水平。与报告高 PA 的参与者相比，PA 极低的参与者患 CVD 的风险几乎增加了两倍。极低的 PA 还与多种与 CVD 相关的危险因素相关，最显着的是甘油三酯升高（比值比 25.4）、肥胖（比值比 1.9）、高血压（比值比 1.4）和糖尿病（比值比 2.3；所有 p < 0.01） ）。随着时间的推移，感染者的 PA 水平较低与心脏代谢疾病风险增加相关。