Dynamic Covalent C═C Bond, Cross-Linked, Injectable, and Self-Healable Hydrogels via Knoevenagel Condensation.,Biomacromolecules

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Dynamic Covalent C═C Bond, Cross-Linked, Injectable, and Self-Healable Hydrogels via Knoevenagel Condensation.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-02-25 , DOI: 10.1021/acs.biomac.9b01689
Caicai Jiao _{1,

2} , Lilong Gao ₁ , Hui Zhang _{1,

2} , Bing Yu _{2,

3,

4} , Hailin Cong _{1,

2,

4} , Youqing Shen _{1,

2,

5}

Affiliation

Hydrogels have a wide range of applications in the fields of biomedicine, flexible electronics, and bionics. In this study, injectable and self-healable hydrogels were first prepared based on a dynamic covalent C═C bond formed via the Knoevenagel condensation reaction between poly(ethylene glycol) dicyanoacetate and water-soluble poly(vanillin acrylate). Three kinds of catalysts (phosphate buffer, zeolitic imidazolate framework-8, and tertiary amine) were used in Knoevenagel condensation for preparing hydrogels. All hydrogels in this study could be formed in situ, and their gelation time ranged from seconds to minutes. The properties and application of hydrogels could be customized according to the type of catalyst employed. 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) results indicated that all the components and hydrogels exhibited low toxicity, and the hydrogels could be used as 3D cell culture scaffolds. Because of the dynamic covalent C═C bond formed by Knoevenagel condensation, the resultant hydrogels were found to be dynamic and showed good self-healing properties. This work presents a new dynamic covalent chemistry for the preparation of self-healable materials.

中文翻译：

通过Knoevenagel缩合的动态共价C═C键，交联，可注射和可自愈的水凝胶。

水凝胶在生物医学，柔性电子学和仿生学领域具有广泛的应用。在这项研究中，首先基于通过聚乙二醇二氰基乙酸酯与水溶性聚香草醛丙烯酸酯之间的Knoevenagel缩合反应形成的动态共价C═C键，制备了可注射和可自愈的水凝胶。在Knoevenagel缩合反应中使用了三种催化剂（磷酸盐缓冲液，沸石咪唑骨架8和叔胺）来制备水凝胶。这项研究中的所有水凝胶都可以原位形成，其胶凝时间从数秒到数分钟不等。水凝胶的性质和应用可以根据所用催化剂的类型进行定制。3- [4,5-二甲基噻唑-2-基] -2，5-二苯基溴化四氮唑（MTT）结果表明，所有成分和水凝胶均显示出低毒性，并且该水凝胶可用作3D细胞培养支架。由于通过Knoevenagel缩合形成的动态共价C═C键，发现生成的水凝胶是动态的，并显示出良好的自愈特性。这项工作提出了一种用于制备自愈材料的新型动态共价化学。

更新日期：2020-02-25

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