Enzymatic Degradation of Bombyx mori Silk Materials: A Review.,Biomacromolecules

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Enzymatic Degradation of Bombyx mori Silk Materials: A Review.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-02-19 , DOI: 10.1021/acs.biomac.0c00090
Chengchen Guo ₁ , Chunmei Li ₁ , David L Kaplan ₁

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As a biomaterial, silk presents unique features with a combination of excellent mechanical properties, biocompatibility, and biodegradability. The biodegradability aspects of silk biomaterials, especially with options to control the rate from short (days) to long (years) time frames in vivo, make this protein-based biopolymer a good candidate for developing biodegradable devices used for tissue repairs and tissue engineering, as well as medical device implants. Silk materials, including native silk fibers and a broad spectrum of regenerated silk materials, have been investigated in vitro and in vivo to demonstrate degradation by proteolytic enzymes. In this Review, we summarize the findings on these studies on the enzymatic degradation of Bombyx mori (B. mori) silk materials. We also present a discussion on the factors that dictate the degradation properties of silk materials. Finally, in future perspectives, we highlight some key challenges and potential directions toward the future study of the degradation of silk materials.

中文翻译：

家蚕丝材料的酶降解：综述。

作为一种生物材料，丝绸具有独特的特性，具有优异的机械性能、生物相容性和生物可降解性。丝生物材料的生物降解性方面，特别是可以控制体内从短（天）到长（年）时间范围内的速率的选项，使这种基于蛋白质的生物聚合物成为开发用于组织修复和组织工程的可生物降解设备的良好候选者，以及医疗设备植入物。丝绸材料，包括天然丝纤维和各种再生丝材料，已经在体外和体内进行了研究，以证明蛋白水解酶的降解作用。在这篇综述中，我们总结了有关家蚕 (B. mori) 丝材料酶促降解的这些研究结果。我们还讨论了决定丝绸材料降解性能的因素。最后，在未来的展望中，我们强调了丝绸材料降解未来研究的一些关键挑战和潜在方向。

更新日期：2020-02-10

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