Myelin oligodendrocyte glycoprotein (MOG) antibody-associated syndromes are now considered a distinct and new entity in the field of CNS inflammatory demyelinating disorders, different from multiple sclerosis and aquaporin4-IgG-positive neuromyelitis optica. MOG antibody-associated syndromes are associated with a young age at onset and are common in children with acquired demyelinating syndrome. Although recent large-scale studies have brought new insight to the field, many open questions still remain, including their prevalence, the entire clinical spectrum, prognostic and predictive factors, and treatment strategies.

中文翻译：

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脱髓鞘疾病和自身免疫性脑炎之间的界限越界。

与多发性硬化症和水通道蛋白4-IgG阳性视神经脊髓炎不同，髓磷脂少突胶质细胞糖蛋白（MOG）抗体相关综合征现在被认为是中枢神经系统炎性脱髓鞘疾病领域中一个独特的新实体。MOG抗体相关综合征与发病年龄低有关，在患有后天性脱髓鞘综合征的儿童中很常见。尽管最近的大规模研究为该领域带来了新的见识，但仍然存在许多悬而未决的问题，包括其患病率，整个临床范围，预后和预测因素以及治疗策略。