This study aimed to develop and test a simultaneous acquisition and analysis pipeline for voxel-based magnetic susceptibility and morphometry (VBMSM) on a single dataset using young volunteers, elderly healthy volunteers, and an Alzheimer's disease (AD) group. 3D T1 -weighted and multi-echo phase images for VBM and quantitative susceptibility mapping (QSM) were simultaneously acquired using a magnetization-prepared spoiled turbo multiple gradient echo sequence with inversion pulse for QSM (MP-QSM). The magnitude image was split into gray matter (GM) and white matter (WM) and was spatially normalized. The susceptibility map was reconstructed from the phase images. The segmented image and susceptibility map were compared with those obtained from conventional multiple spoiled gradient echo (mGRE) and MP-spoiled gradient echo (MP-GRE) in healthy volunteers to validate the availability of MP-QSM by numerical measurements. To assess the feasibility of the VBMSM analysis pipeline, voxel-based comparisons of susceptibility and morphometry in MP-QSM were conducted in volunteers with a bimodal age distribution, and in elderly volunteers and the AD group, using spatially normalized GM and WM volume images and a susceptibility map. GM/WM contrasts in MP-QSM, MP-GRE, and mGRE were 0.14 ± 0.011, 0.17 ± 0.015, and 0.045 ± 0.010, respectively. Segmented GM and WM volumes in the MP-QSM closely coincided with those in the MP-GRE. Region of interest analyses indicated that the mean susceptibility values in MP-QSM were completely in agreement with those in mGRE. In an evaluation of the aging effect, a significant increase and decrease in susceptibility and volume were found by VBMSM in deep GM and WM, respectively. Between the elderly volunteers and the AD group, the characteristic susceptibility and volume changes in GM and WM were observed. The proposed MP-QSM sequence makes it possible to acquire acceptable-quality images for simultaneous analysis and determine brain atrophy and susceptibility distribution without image registration by using voxel-based analyses.

中文翻译：

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同时基于体素的磁化率和形态分析，使用磁化制备的变质涡轮多重梯度回波进行。

这项研究旨在使用年轻志愿者，老年健康志愿者和阿尔茨海默氏病（AD）组，在单个数据集上开发和测试基于体素的磁化率和形态测量（VBMSM）的同步采集和分析管道。使用磁化准备的，带有反脉冲的QSM扰动涡轮多梯度回波序列（MP-QSM）同时获取VBM的3D T1加权和多回波相位图像和定量磁化率映射（QSM）。幅值图像分为灰质（GM）和白质（WM），并在空间上进行了归一化。从相图重建磁化率图。将分割的图像和磁化率图与从健康志愿者中常规多重扰动梯度回波（mGRE）和MP扰动梯度回波（MP-GRE）获得的图像和磁化率图进行比较，以通过数值测量验证MP-QSM的可用性。为了评估VBMSM分析流程的可行性，我们使用空间归一化的GM和WM体积图像，对具有双峰年龄分布的志愿者以及老年志愿者和AD组进行了基于体素的MP-QSM敏感性和形态学比较。磁化率图。MP-QSM，MP-GRE和mGRE中的GM / WM对比度分别为0.14±0.011、0.17±0.015和0.045±0.010。MP-QSM中分段的GM和WM量与MP-GRE中的分段量非常吻合。感兴趣区域分析表明，MP-QSM中的平均磁化率值与mGRE中的磁化率值完全一致。在评估衰老效果时，深部GM和WM的VBMSM分别发现药敏性和体积显着增加和减少。在老年志愿者和AD组之间，观察到了GM和WM的特征敏感性和体积变化。所提出的MP-QSM序列使得可以获取质量合格的图像以进行同时分析，并通过基于体素的分析无需图像配准即可确定脑萎缩和磁化率分布。在老年志愿者和AD组之间，观察到了GM和WM的特征敏感性和体积变化。所提出的MP-QSM序列使得可以获取质量合格的图像以进行同时分析，并通过基于体素的分析无需图像配准即可确定脑萎缩和磁化率分布。在老年志愿者和AD组之间，观察到了GM和WM的特征敏感性和体积变化。所提出的MP-QSM序列使得可以获取质量合格的图像以进行同时分析，并通过基于体素的分析无需图像配准即可确定脑萎缩和磁化率分布。