Plants regulate the synthesis of specialized compounds through the actions of individual transcription factors (TFs) or sets of TFs. One such compound, artemisinin from Artemisia annua, is widely used as a pharmacological product in the first-line treatment of malaria. However, the emergence of resistance to artemisinin in Plasmodium species, as well as its low production rates, have required innovative treatments such as exploiting the synergistic effects of flavonoids with artemisinin. We overview current knowledge about flavonoid and artemisinin transcriptional regulation in A. annua, and review the dual action of TFs and structural genes that can regulate both pathways simultaneously. Understanding the concerted action of these TFs and their associated structural genes can guide the development of strategies to further improve flavonoid and artemisinin production.

植物通过单个转录因子（TF）或TF组的作用来调节特殊化合物的合成。一种这样的化合物，即来自青蒿的青蒿素，被广泛用作一线治疗疟疾的药理产品。然而，在疟原虫物种中出现对青蒿素的抗性及其低生产率，需要创新的治疗方法，例如利用类黄酮与青蒿素的协同作用。我们概述了当前有关黄酮和青蒿素转录调控的知识。，并审查可同时调节两条途径的TF和结构基因的双重作用。了解这些TF及其相关结构基因的协同作用可以指导策略的发展，以进一步改善类黄酮和青蒿素的生产。