Background and Purpose- We evaluated whether hemoglobin concentration at admission was associated with stroke recurrence and composite vascular events (stroke, myocardial infarction, and vascular death) in acute ischemic stroke. Methods- We collected data from patients with acute ischemic stroke or transient ischemic attack from a multicenter stroke registry database in Korea. The association of hemoglobin concentration with 1-year stroke recurrence and composite vascular events was evaluated with respect to age, presence of cerebral artery stenosis, stroke severity, and stroke subtype. Results- Hemoglobin levels were inversely associated with stroke recurrence and composite vascular events. One-year rates of stroke recurrence and composite vascular events were significantly higher in patients with anemia or moderate anemia. In multivariable analyses, moderate anemia remained an independent predictor of stroke recurrence (adjusted hazard ratio, 1.43 [95% CI, 1.16-1.75]) and composite vascular events (adjusted hazard ratio, 1.26 [95% CI, 1.07-1.48]). Moderate anemia increased the risk of composite vascular events in patients with mild-to-moderate stroke severity (National Institutes of Health Stroke Scale score <16, P=0.01 for interaction). Conclusions- Hemoglobin concentration could be an independent predictor of stroke recurrence and composite vascular events.

中文翻译：

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血红蛋白浓度对中风复发和复合血管事件的影响。

背景和目的-我们评估了急性缺血性卒中入院时血红蛋白浓度是否与卒中复发和复合血管事件（中风，心肌梗塞和血管死亡）相关。方法-我们从韩国的多中心卒中注册数据库中收集了急性缺血性卒中或短暂性脑缺血发作患者的数据。根据年龄，脑动脉狭窄的存在，中风的严重性和中风亚型，评估了血红蛋白浓度与1年中风复发和复合血管事件的相关性。结果-血红蛋白水平与中风复发和复合血管事件呈负相关。贫血或中度贫血患者的中风复发和复合血管事件的一年发生率显着更高。在多变量分析中，中度贫血仍然是卒中复发（调整后的危险比，1.43 [95％CI，1.16-1.75]）和复合血管事件（调整后的危险比，1.26 [95％CI，1.07-1.48]）的独立预测因子。中度贫血增加中度至中度卒中严重程度患者的复合血管事件风险（美国国立卫生研究院卒中量表评分<16，相互作用P = 0.01）。结论：血红蛋白浓度可能是卒中复发和复合血管事件的独立预测因子。中度贫血增加中度至中度卒中严重程度患者的复合血管事件风险（美国国立卫生研究院卒中量表评分<16，相互作用P = 0.01）。结论：血红蛋白浓度可能是卒中复发和复合血管事件的独立预测因子。中度贫血增加中度至中度卒中严重程度患者的复合血管事件风险（美国国立卫生研究院卒中量表评分<16，相互作用P = 0.01）。结论：血红蛋白浓度可能是卒中复发和复合血管事件的独立预测因子。