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Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia.
Translational Psychiatry ( IF 5.8 ) Pub Date : 2020-02-11 , DOI: 10.1038/s41398-020-0746-5
Yongjie Zhou 1, 2 , Yuhuan Li 3 , Yujie Meng 3 , Jiesi Wang 4 , Fengchun Wu 5 , Yuping Ning 5 , Yi Li 1, 2 , Ryan M Cassidy 6 , Zezhi Li 7 , Xiang Yang Zhang 4
Affiliation  

There is evidence that obesity or higher body mass index is correlated with cognitive impairment in schizophrenia. Recent studies have demonstrated that genetic risk factors, such as the NRG3, are correlated with both elevated BMI and reduced cognitive function. In present study, we aimed to determine whether possession of the NRG3 rs10748842 influences the correlation between elevated BMI and reduced cognitive ability in schizophrenia. To our knowledge, this has never been examined before. A total of 625 inpatients with schizophrenia and 400 controls were recruited. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to assess cognitive function. We used multiple analysis of covariance (MANCOVA), analyses of covariance (ANCOVA), Pearson correlations, partial correlations, and multivariate regression analysis to test the influence of NRG3 rs10748842 on the aforementioned variables. All RBANS five sub-scores and total score were lower in patients than those in controls (all p < 0.001). Patients carrying NRG3 rs10748842 TC + CC heterozygous genotype had lower attention score compared to TT homozygous genotype (adjusted F = 4.77, p = 0.029). BMI was positively associated with language score in patients (β = 0.387, t = 2.59, p = 0.01). Interestingly, we further found positive association between BMI and language score in TT carriers (partial correlations: r = 0.13, adjusted p = 0.004; multivariate regression: β = 0.42, t = 2.66, p = 0.008), but not in CT + CC carrier (p > 0.05). Our study demonstrated that NRG3 rs10748842 was associated with cognitive impairments, especially attention performance in schizophrenia. Moreover, NRG3 rs10748842 altered the effect of BMI on cognitive impairments as measured by the RBANS language score in chronic patients with schizophrenia.

中文翻译:


Neuregulin 3 rs10748842 多态性有助于体重指数对精神分裂症患者认知障碍的影响。



有证据表明肥胖或较高的体重指数与精神分裂症的认知障碍相关。最近的研究表明,NRG3 等遗传风险因素与 BMI 升高和认知功能下降相关。在本研究中,我们旨在确定 NRG3 rs10748842 的拥有是否会影响精神分裂症患者 BMI 升高和认知能力下降之间的相关性。据我们所知,此前从未对此进行过检验。总共招募了 625 名住院精神分裂症患者和 400 名对照者。进行神经心理状态评估的可重复电池组(RBANS)来评估认知功能。我们使用多元协方差分析(MANCOVA)、协方差分析(ANCOVA)、Pearson相关、偏相关和多元回归分析来测试NRG3 rs10748842对上述变量的影响。患者的所有 RBANS 五个子评分和总评分均低于对照组(所有 p < 0.001)。与 TT 纯合基因型相比,携带 NRG3 rs10748842 TC + CC 杂合基因型的患者注意力评分较低(调整后的 F = 4.77,p = 0.029)。 BMI 与患者语言评分呈正相关(β = 0.387,t = 2.59,p = 0.01)。有趣的是,我们进一步发现 TT 携带者的 BMI 和语言分数之间存在正相关(部分相关:r = 0.13,调整后的 p = 0.004;多元回归:β = 0.42,t = 2.66,p = 0.008),但在 CT + CC 中则不然载体(p > 0.05)。我们的研究表明,NRG3 rs10748842 与认知障碍相关,尤其是精神分裂症患者的注意力表现。 此外,NRG3 rs10748842 改变了 BMI 对慢性精神分裂症患者的 RBANS 语言评分所测量的认知障碍的影响。
更新日期:2020-02-11
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