Soft tissue pressure injuries commonly occur in those with spinal cord injury. They add an immeasurable medical, emotional, and social burden to those who suffer a spinal cord injury and ultimately can cause death due to sepsis when they ulcerate and become infected. Hence it is notable that (i) obstructive sleep apnea and other forms of sleep-disordered breathing are highly prevalent among those with spinal cord injury; (ii) several of the pathophysiologic consequences of sleep-disordered breathing, including hypoxemia, ischemia, oxidative stress, and endothelial dysfunction, would be expected to increase susceptibility to pressure injuries, worsen their severity, and slow or prevent their healing; and (iii) there is emerging clinical evidence that sleep-disordered breathing can have a significant role in the pathogenesis of other types of chronic wounds and that treatment of sleep-disordered breathing can aid in the healing of these wounds. These findings raise the possibility that sleep-disordered breathing may have a widespread and important role in the development, severity, and persistence of pressure injuries in those with spinal cord injury and that treatment of sleep-disordered breathing may be an effective adjunct in their prevention and healing. Studies to determine if there is a functional relationship between sleep-disordered breathing and pressure injuries in individuals with spinal cord injury are warranted.

中文翻译：

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在患有脊髓损伤的患者中，睡眠呼吸障碍在压力损伤发展和延迟愈合中具有潜在的广泛而重要的作用。

软组织压力损伤通常发生在脊髓损伤的患者中。它们给那些遭受脊髓损伤的人增加了不可估量的医疗，情感和社会负担，并最终在他们溃疡并受到感染时因败血症而导致死亡。因此，值得注意的是：（i）阻塞性睡眠呼吸暂停和其他形式的睡眠呼吸障碍在脊髓损伤者中非常普遍；（ii）预计睡眠呼吸障碍的几种病理生理后果，包括低氧血症，局部缺血，氧化应激和内皮功能障碍，将增加对压力性损伤的敏感性，加重其严重程度，并减慢或阻止其愈合；（iii）越来越多的临床证据表明，睡眠呼吸障碍可能在其他类型的慢性伤口的发病机理中起着重要作用，而睡眠呼吸障碍的治疗可以帮助这些伤口的愈合。这些发现增加了睡眠呼吸障碍可能在脊髓损伤患者的压力损伤的发生，严重程度和持续性方面具有广泛而重要的作用，而睡眠呼吸障碍的治疗可能是预防这些疾病的有效辅助手段。和愈合。有必要进行研究以确定在患有脊髓损伤的个体中睡眠呼吸障碍和压力损伤之间是否存在功能关系。这些发现增加了睡眠呼吸障碍可能在脊髓损伤患者的压力损伤的发生，严重程度和持续性方面具有广泛而重要的作用，而睡眠呼吸障碍的治疗可能是预防这些疾病的有效辅助手段。和愈合。有必要进行研究以确定在患有脊髓损伤的个体中睡眠呼吸障碍和压力损伤之间是否存在功能关系。这些发现增加了睡眠呼吸障碍可能在脊髓损伤患者的压力损伤的发生，严重程度和持续性方面具有广泛而重要的作用，而睡眠呼吸障碍的治疗可能是预防这些疾病的有效辅助手段。和愈合。有必要进行研究以确定在患有脊髓损伤的个体中睡眠呼吸障碍和压力损伤之间是否存在功能关系。