The amphiphilic copolymer polystyrene-maleic anhydride (SMA)-2-hydroxyethyl acrylate (HEA) was synthesized for the first time in this study, and used as a linker to graft zwitterionic sulfobetaine methacrylate (SBMA) in order to enhance the hydrophilicity and anti-adsorption ability of polyvinylidene difluoride (PVDF) membranes. This amphiphile linker is composed of a hydrophobic extremity, i.e., the SMA copolymer, and a hydrophilic extremity, i.e., the HEA. The SMA-HEA linker was first dispersed into the PVDF matrix via the blending method, and the hydrophobic polystyrene of SMA was adsorbed into the PVDF membrane via hydrophobic–hydrophobic interaction. The SBMA was then grafted onto the expanded HEA via free radical polymerization. The functional groups, morphologies, and hydrophilicity of the amphiphile-modified PVDF membranes were analyzed by attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), field emission scanning electron microscopy (FE-SEM), and water contact angle (WCA) measurements. The PVDF membrane modified with the SMA-HEA amphiphile linker showed significant enhancement in hydrophilicity as the WCA decreased from 135.0° to 45.0°, and the protein adsorption of the modified membrane decreased from 112.5 to 33.3 μg⋅cm⁻². Furthermore, dynamic protein separation was performed, and the pure water flux recovery rate reached 100%, indicating good anti-adsorption ability.

本研究首次合成了两亲性共聚物聚苯乙烯-马来酸酐（SMA）-2-羟乙基丙烯酸酯（HEA），并用作接枝两性离子磺基甜菜碱甲基丙烯酸酯（SBMA）的接头，以增强亲水性和抗聚偏二氟乙烯（PVDF）膜的吸附能力。该两亲性接头由疏水性末端，即SMA共聚物，和亲水性末端，即HEA组成。首先通过共混法将SMA-HEA接头分散到PVDF基质中，然后通过疏水-疏水相互作用将SMA的疏水聚苯乙烯吸附到PVDF膜中。然后通过自由基聚合将SBMA接枝到扩展的HEA上。功能组，形态，通过衰减全反射傅里叶变换红外光谱（ATR-FTIR），场发射扫描电子显微镜（FE-SEM）和水接触角（WCA）测量来分析两亲修饰的PVDF膜的亲水性和亲水性。SMA-HEA两亲性接头修饰的PVDF膜的亲水性显着增强，因为WCA从135.0°降低到45.0°，并且修饰膜的蛋白质吸附从112.5降低到33.3μg·cm⁻²。此外，进行了动态蛋白质分离，纯水通量回收率达到100％，表明具有良好的抗吸附能力。