Due to the enhanced nano-bio interactions, nanoparticles with a rough surface have attracted a great deal of attention in nanomedicine. However, the low surface area of the rough nanoparticles is not suitable for drug loading. It is still a great challenge to increase the surface area of the nanocarriers without affecting the rough surface architecture. Here, a dual-component asymmetric structured mesoporous “nanotruck” is rationally synthesized by the interfacial-energy-mediated anisotropic growth strategy. The nanotruck possesses distinguished dual domains of spherical SiO₂ head with rough surface (rSiO₂) as an “engine” for enhanced nano-bio interactions, and periodic mesoporous organosilica (PMO) nanorod with a high surface area of ∼ 794 m²/g as a “trailer” for efficient drug loading. By embedding a dual-mode up-downconversion luminescent nanoparticle in rSiO₂ head, the nanotrucks exhibit not only unique intensive interaction with tumor cells, long blood circulation and efficient tumor accumulation, but also NIR bio-imaging-guided controllable drug release.

由于增强的纳米生物相互作用，具有粗糙表面的纳米颗粒在纳米医学中引起了极大的关注。但是，粗糙的纳米颗粒的低表面积不适合载药。在不影响粗糙表面结构的情况下增加纳米载体的表面积仍然是巨大的挑战。在此，通过界面能量介导的各向异性生长策略合理地合成了双组分非对称结构的介孔“ nanotruck”。纳米卡车具有独特的球形SiO ₂头双域，具有粗糙的表面（rSiO ₂）作为增强纳米生物相互作用的“引擎”，以及周期性的介孔有机硅（PMO）纳米棒，具有约794 m ²的高表面积。/ g作为有效药物加载的“预告片”。通过在rSiO ₂头中嵌入双模上/下转换发光纳米颗粒，纳米卡车不仅表现出与肿瘤细胞的独特密集相互作用，长血循环和有效的肿瘤积累，而且还表现出NIR生物成像引导的可控药物释放。