Abstract

The incidence and mortality from colorectal cancer in younger adults (younger than 55 years) is increasing. We reviewed the complete database of a gene-expression test, Oncotype DX Colon Recurrence Score test, to determine age-related differences in recurrence score (RS) and single-gene results (7 cancer-related of the 12-gene assay). We included 20 478 stage II and III A and B colon cancer patients submitted to Genomic Health. RS results were grouped by low-, intermediate-, and high-risk groups. Single-gene scores were described using median and interquartile range. Of all patients 72.5% and 72.6% of those younger than 40 years had low-risk RS. Comparing older with younger patients, RS or single-gene expression did not differ by age group or stage. Young-onset colon cancer does not differ by expression of the RS component genes. Most patients with stage II and III colon cancer have low-risk disease as measured by the 12-gene assay, regardless of age.

中文翻译：

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基因表达的年轻结肠癌和复发风险。

摘要

年轻人（55 岁以下）结直肠癌的发病率和死亡率正在增加。我们审查了基因表达测试的完整数据库，Oncotype DX 结肠复发评分测试，以确定复发评分 (RS) 和单基因结果（12 基因检测中的 7 个癌症相关）的年龄相关差异。我们纳入了提交给 Genomic Health 的 20 478 名 II 期和 III 期 A 和 B 期结肠癌患者。RS 结果按低、中和高风险组分组。使用中位数和四分位距描述单基因评分。在所有患者中，72.5% 和 72.6% 的 40 岁以下患者患有低风险 RS。将老年患者与年轻患者进行比较，RS 或单基因表达在年龄组或阶段没有差异。年轻发病的结肠癌不会因 RS 成分基因的表达而异。