Cancer cachexia is a life‐threatening metabolic syndrome that causes significant loss of skeletal muscle mass and significantly increases mortality in cancer patients. Currently, there is an urgent need for better understanding of the molecular pathophysiology of this disease so that effective therapies can be developed. The majority of pre‐clinical studies evaluating skeletal muscle's response to cancer have focused on one or two pre‐clinical models, and almost all have focused specifically on limb muscles. In the current study, we reveal key differences in the histology and transcriptomic signatures of a limb muscle and a respiratory muscle in orthotopic pancreatic cancer patient‐derived xenograft (PDX) mice.

中文翻译：

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对小鼠肢体和呼吸肌中人类胰腺肿瘤的不同恶病质特征。

癌症恶病质是一种危及生命的代谢综合征，会导致骨骼肌质量显着下降，并显着增加癌症患者的死亡率。目前，迫切需要更好地了解这种疾病的分子病理生理学，以便开发有效的治疗方法。大多数评估骨骼肌对癌症反应的临床前研究都集中在一个或两个临床前模型上，而且几乎所有研究都专门针对肢体肌肉。在目前的研究中，我们揭示了原位胰腺癌患者来源的异种移植（PDX）小鼠肢体肌肉和呼吸肌的组织学和转录组学特征的关键差异。