Abstract

Summary

IGF-1 and leptin are two nutritionally dependent hormones associated with low bone mass in women with anorexia nervosa. Using finite element analysis, we estimated bone strength in women with anorexia nervosa and found that IGF-1 but not leptin correlated significantly with estimated bone strength in both the radius and tibia.

Purpose

Women with anorexia nervosa, a psychiatric disorder characterized by self-induced starvation and low body weight, have impaired bone formation, low bone mass, and an increased risk of fracture. IGF-1 and leptin are two nutritionally dependent hormones that have been associated with low bone mass in women with anorexia nervosa. We hypothesized that IGF-1 and leptin would also be positively associated with estimated bone strength in women with anorexia nervosa.

Methods

In this cross-sectional study of 38 women (19 with anorexia nervosa and 19 normal-weight controls), we measured serum IGF-1 and leptin and performed finite element analysis of high-resolution peripheral quantitative CT images to measure stiffness and failure load of the distal radius and tibia.

Results

IGF-1 was strongly correlated with estimated bone strength in the radius (R = 0.52, p = 0.02 for both stiffness and failure load) and tibia (R = 0.55, p = 0.01 for stiffness and R = 0.58, p = 0.01 for failure load) in the women with anorexia nervosa but not in normal-weight controls. In contrast, leptin was not associated with estimated bone strength in the group of women with anorexia nervosa or normal-weight controls.

Conclusions

IGF-1 is strongly associated with estimated bone strength in the radius and tibia in women with anorexia nervosa. Further studies are needed to assess whether treatment with recombinant human IGF-1 will further improve bone strength and reduce fracture risk in this population.

中文翻译：

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IGF-1与神经性厌食症的估计骨强度有关

摘要

概要

IGF-1和瘦素是神经营养性厌食症女性中与骨量低有关的两种营养依赖性激素。使用有限元分析，我们估计了神经性厌食症女性的骨强度，发现IGF-1但瘦素与not骨和胫骨的骨强度均无显着相关性。

目的

神经性厌食症是一种以自我诱发的饥饿和低体重为特征的精神病性疾病的女性，其骨形成受损，骨量低和骨折的风险增加。IGF-1和瘦素是两种营养依赖性激素，与神经性厌食症女性的骨量低有关。我们假设，IGF-1和瘦素也与神经性厌食症妇女的骨强度估计值呈正相关。

方法

在本项针对38名女性（19名神经性厌食症和19名体重正常对照）的横断面研究中，我们测量了血清IGF-1和瘦素，并对高分辨率外周定量CT图像进行了有限元分析，以测量僵硬和失败负荷。远端radius骨和胫骨。

结果

IGF-1与estimated骨的估计骨强度（R = 0.52，对于刚度和破坏载荷，p = 0.02）和胫骨（R = 0.55，p = 0.01，对刚度，R = 0.58，p = 0.01 ，对骨强度有很强的相关性。神经性厌食症的女性，但体重控制正常的女性则没有。相反，在神经性厌食症或体重正常的女性中，瘦素与估计的骨强度无关。

结论

IGF-1与神经性厌食症妇女的the骨和胫骨的骨强度估计值密切相关。还需要进一步的研究来评估重组人IGF-1的治疗是否会进一步改善该人群的骨强度并降低骨折风险。