PURPOSE To investigate possible refractive changes in pregnant women who have previously undergone myopic laser in situ keratomileusis (LASIK). METHODS This prospective study included 64 pregnant women (128 eyes) who had previously undergone bilateral myopic LASIK. Uncorrected distance visual acuity (UDVA), spherical equivalent, corneal keratometry, topography and tomography, and epithelial mapping were evaluated before LASIK, 12 months after LASIK, during the third trimester of pregnancy, and 1 year postpartum. RESULTS The average age at the time of recruitment was 32.5 ± 5 years (range: 24.5 to 39.5 years). The evaluation during pregnancy was at an average 55 months (range: 12 to 108 months) from the initial LASIK procedure. The preoperative mean refractive error was -6.72 ± 2.96 diopters (D) (range: -1.00 to -11.00 D). Comparing 12-month refractive data after the original LASIK procedure to the those within the third trimester of the subsequent pregnancy, the average UDVA was 20/18, the residual refractive error was -0.63 ± 1.00 to -0.51 ± 0.82 D, the steepest keratometry value was 40.85 ± 1.89 to 40.88 ± 2.84 D, and the central epithelial thickness was 56.4 ± 3.89 to 57.38 ± 5.04 µm, respectively. CONCLUSIONS In this study, pregnancy did not affect the refractive stability of LASIK. Pregnancy-related changes in refractive error, corneal stability, and total corneal and epithelial thickness in women after LASIK were not found to be statistically significant. [J Refract Surg. 2022;36(2):118-122.].

中文翻译：

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近视LASIK术后妊娠会影响屈光度和角膜稳定性或角膜上皮重塑吗？

目的探讨先前经历过近视激光原位角膜磨镶术（LASIK）的孕妇可能发生的屈光改变。方法这项前瞻性研究纳入了64位曾接受过双侧近视LASIK的孕妇（128眼）。在LASIK术前，LASIK术后12个月，妊娠中期和产后1年，对未矫正的远距离视力（UDVA），球等效值，角膜角膜地形图，断层扫描和上皮标测进行评估。结果招募时的平均年龄为32.5±5岁（范围：24.5至39.5岁）。从最初的LASIK手术开始，怀孕期间的评估平均为55个月（范围：12到108个月）。术前平均屈光不正为-6.72±2.96屈光度（D）（范围：-1.00至-11.00 D）。将原始LASIK手术后的12个月屈光数据与随后妊娠的三个月内的屈光数据进行比较，平均UDVA为20/18，残余屈光误差为-0.63±1.00至-0.51±0.82 D，这是最陡的角膜测量法值是40.85±1.89至40.88±2.84D，中央上皮厚度分别是56.4±3.89至57.38±5.04μm。结论在这项研究中，怀孕并未影响LASIK的屈光稳定性。未发现LASIK术后妇女与妊娠相关的屈光不正，角膜稳定性以及角膜和上皮总厚度的变化无统计学意义。[J Refract Surg。2022; 36（2）：118-122。]。残余屈光误差为-0.63±1.00至-0.51±0.82 D，最陡角膜测量值为40.85±1.89至40.88±2.84 D，中央上皮厚度分别为56.4±3.89至57.38±5.04 µm。结论在这项研究中，怀孕并未影响LASIK的屈光稳定性。未发现LASIK术后妇女与妊娠相关的屈光不正，角膜稳定性以及角膜和上皮总厚度的变化无统计学意义。[J Refract Surg。2022; 36（2）：118-122。]。残余屈光误差为-0.63±1.00至-0.51±0.82 D，最陡角膜测量值为40.85±1.89至40.88±2.84 D，中央上皮厚度分别为56.4±3.89至57.38±5.04 µm。结论在这项研究中，怀孕并未影响LASIK的屈光稳定性。未发现LASIK术后妇女与妊娠相关的屈光不正，角膜稳定性以及角膜和上皮总厚度的变化无统计学意义。[J Refract Surg。2022; 36（2）：118-122。]。LASIK术后女性的角膜稳定性以及总的角膜和上皮厚度没有统计学意义。[J Refract Surg。2022; 36（2）：118-122。]。LASIK术后女性的角膜稳定性以及总的角膜和上皮厚度没有统计学意义。[J Refract Surg。2022; 36（2）：118-122。]。