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The synthesis of fluorescent benzofuro[2,3-c]pyridines via palladium-catalyzed heteroaromatic C–H addition and sequential tandem cyclization
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020/02/10 , DOI: 10.1039/c9qo01491h
Wenzhang Xiong 1, 2, 3, 4 , Zhongyan Chen 1, 2, 3, 4 , Yinlin Shao 1, 2, 3, 4 , Renhao Li 3, 4, 5, 6 , Kun Hu 1, 2, 3, 4 , Jiuxi Chen 1, 2, 3, 4
Affiliation  

A Pd-catalyzed tandem reaction of 2-(cyanomethoxy)chalcones with thiophenes through direct C–H addition and sequential intramolecular conjugate addition/cyclization/aromatization provides a diverse range of 3-aryl-1-(thiophen-2-yl)benzofuro[2,3-c]pyridines. A representative product was assessed as a ratiometric fluorescent probe for Hg2+. This chemistry could also be applied to the synthesis of other fused ring systems.

中文翻译:

通过钯催化杂芳族CHH加成和顺序串联环化反应合成荧光苯并呋喃[2,3-c]吡啶

通过直接C–H加成和分子内共轭物加成/环化/芳构化的Pd催化的2-(氰基甲氧基)查耳酮与噻吩的串联反应提供了范围广泛的3-芳基-1-(噻吩-2-基)苯并呋喃[ 2,3- c ]吡啶。代表性产品被评估为Hg 2+的比例荧光探针。该化学方法也可以应用于其他稠环系统的合成。
更新日期:2020-03-03
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