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Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-02-18 , DOI: 10.1039/d0cc00192a Ana R Araújo 1 , Sergio Camero 2 , Pablo Taboada 3 , Rui L Reis 1 , Ricardo A Pires 1
Chemical Communications ( IF 4.3 ) Pub Date : 2020-02-18 , DOI: 10.1039/d0cc00192a Ana R Araújo 1 , Sergio Camero 2 , Pablo Taboada 3 , Rui L Reis 1 , Ricardo A Pires 1
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The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.
中文翻译：
Vescalagin和Castalagin通过重构其二级结构来降低淀粉样β42寡聚物的毒性。
vescalagin和Castalagin异构体可保护SH-SY5Y细胞免受Aβ42介导的死亡。通过维斯卡林可更好地实现这一点，这是由于其维他糖基在糖苷链C1位的空间结构，提高了其重塑毒性Aβ42低聚物二级结构的能力。
更新日期：2020-03-12
中文翻译：
Vescalagin和Castalagin通过重构其二级结构来降低淀粉样β42寡聚物的毒性。
vescalagin和Castalagin异构体可保护SH-SY5Y细胞免受Aβ42介导的死亡。通过维斯卡林可更好地实现这一点，这是由于其维他糖基在糖苷链C1位的空间结构，提高了其重塑毒性Aβ42低聚物二级结构的能力。
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